Improvements achieved in an oocyte donation program over a 10-year period: sequential increase in implantation and pregnancy rates and decrease in high-order multiple pregnancies

doi:10.1016/j.fertnstert.2006.11.118

Fertility and Sterility

Volume 88, Issue 2, August 2007, Pages 342-349

https://doi.org/10.1016/j.fertnstert.2006.11.118 Get rights and content

Objective

To compare outcome parameters and cumulative pregnancy rates (PRs) in oocyte donation cycles over a period of 10 years.

Design

Retrospective study.

Setting

University-affiliated assisted reproductive technology program.

Patient(s)

Women undergoing oocyte donation (10,537 cycles) between 1995 and 2005.

Intervention(s)

Ovarian stimulation and oocyte retrieval in donors. Embryo transfer performed in recipients after endometrial preparation.

Main Outcome Measure(s)

Outcome parameters and cumulative PRs were calculated and compared in relation to indication, age, and origin of sperm used.

Result(s)

Overall PR, implantation rate, clinical PR, and miscarriage rate per embryo transfer performed were 54.9%, 27%, 50.3%, and 19%, respectively. Ongoing PR per transfer was 40.2%, and twin and high-order multiple PRs were 39% and 6%, respectively. Mean number of embryos transferred was reduced from 3.6 ± 0.8 to 1.9 ± 0.3, implantation rate improved from 16.7% to 38.3%, and ongoing PR improved from 31% to 44.3%. Cumulative PRs did not differ significantly among different indications for oocyte donation, age groups, or origin of sperm used for oocyte insemination. Overall cumulative PRs after three and five cycles were calculated as 87% and 96.8%, respectively.

Conclusion(s)

Significant improvements in outcome parameters were achieved within 10 years. Similar cumulative PRs were observed regardless of recipient age, indication for oocyte donation, or sperm origin.

Section snippets

Materials and methods

Data from oocyte donation cycles were searched in a computer database between September 1, 1995, and September 30, 2005. A total of 11,515 cycles were initiated during this period; however, 2,107 cycles (18.2%) were cancelled before oocyte retrieval and donation. The high number of cancellation in cycles initiated was due to various factors, including inadequate endometrial thickness, endometrial bleeding during hormonal preparation, donor cancellation (for reasons including poor administration

Results

Oocyte donation was performed in 8,430 cycles and embryo transfer procedure in 7,186 cycles from the total of 10,537 cycles initiated. Cycle outcome parameters calculated according to number of cycles initiated, number of donations, and embryo transfer procedures performed are shown in Table 1.

In this study, we aimed to study the evolution of our oocyte donation program over a 10-year period and furthermore the effect of recipient age, indication for oocyte donation, and severity of male factor

Discussion

The first oocyte donation cycle was performed in 1983, and 1 year later the first delivery of a healthy baby was reported of a women with POF (12, 13). In our institution, we have been performing egg donation for 15 years and presently have one of the largest oocyte donation programs in Europe. Our initial 5-year experience with oocyte donation and cumulative pregnancy and live birth rates was published by Remohi et al. presenting data from 627 embryo transfers performed between January 1991

Acknowledgments

The authors express public recognition to all the members of our staff at Instituto Valenciano de Infertilidad Valencia.

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In vitro fertilizationImprovements achieved in an oocyte donation program over a 10-year period: sequential increase in implantation and pregnancy rates and decrease in high-order multiple pregnancies

Objective

Design

Setting

Patient(s)

Intervention(s)

Main Outcome Measure(s)

Result(s)

Conclusion(s)

Section snippets

Materials and methods

Results

Discussion

Acknowledgments

Fertil Steril

Fertil Steril

Reprod Biomed Online

Fertil Steril

Reprod Biomed Online

Fertil Steril

Fertil Steril

Semin Perinatol

Fertil Steril

Am J Obstet Gynecol

Fertil Steril

Fertil Steril

Fertil Steril

Assisted reproductive technology in Europe, 2001Results generated from European registers by ESHRE

Hum Reprod

Long oestradiol replacement in an oocyte donation programme

Hum Reprod

In vitro fertilization
Improvements achieved in an oocyte donation program over a 10-year period: sequential increase in implantation and pregnancy rates and decrease in high-order multiple pregnancies