CorrespondenceIncreased type I and V collagen expression in uterine leiomyomas during the menstrual cycle
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Cited by (21)
Progesterone signaling in uterine leiomyoma biology: Implications for potential targeted therapy
2024, Advances in Medical SciencesIn vivo mechanisms of uterine myoma volume reduction with ulipristal acetate treatment
2015, Fertility and SterilityCitation Excerpt :Myomas are characterized by their abundant ECM, and it is likely that collagen and ECM-associated glycoprotein deposits increase as the tumor develops (47). Myomas are richer in collagen type I than normal myometrium (48–50). The present study demonstrated a global decrease in the ECM volume fraction of myomas after long-term treatment with UPA compared to untreated myomas.
Complex networks of multiple factors in the pathogenesis of uterine leiomyoma
2013, Fertility and SterilityCitation Excerpt :Besides, relative overexpression of types I and III collagen mRNAs was found in leiomyomas compared with the adjacent myometrium (177, 192). Furthermore, increased expression of type I and Vcollagen at protein level was observed in leiomyomas compared with normal myometrium (181, 193). Recently Malik et al. (180) tested a series of collagen subtypes; among these COL1A1, 4A2, 6A1, 6A2, 7A1, and 16A1 are expressed to a greater extent in leiomyoma cells compared with myometrial cells.
Treatment for uterine fibroids: Searching for effective drug therapies
2012, Drug Discovery Today: Therapeutic StrategiesCitation Excerpt :However, targeting TGFβ is problematic, requiring progteins as therapeutics (cost, purity, stability, immune response) and manipulating TGFβ signaling inhibition, preventing its widespread usage. Fibroids are characterized by altered collagen fibrils, fibrosis and tissue stiffness [37,38], as well as increased amounts of type I and V collagen [39]. Selective elimination of collagen producing cells or reducing their state of activation is currently limited to experimental trials.
Periostin’s role in uterine leiomyoma development: a mini-review on the potential periostin poses as a pharmacological intervention for uterine leiomyoma
2024, Archives of Gynecology and Obstetrics
M.I. has nothing to disclose. Y.M. has nothing to disclose.