Original articleLive birth after transplantation of frozen-thawed ovarian tissue after bilateral oophorectomy for benign disease
Section snippets
Materials and methods
In December 2001, the patient, who was 18 years of age at the time, underwent laparoscopy followed by midline laparotomy for peritonitis, appendectomy, and partial resection of the cecum. In February 2002, she developed clinical features of PID that resolved with antibiotic therapy. In June 2002, laparotomy was carried out for recurrent PID. Because of the presence of large 10-cm in diameter tubo-ovarian abscesses, bilateral salpingo-oophorectomy was carried out. Owing to extensive inflammation
Ovarian Biopsy after Cryopreservation
Histological examination of a sample of cryopreserved ovarian tissue thawed at the time of transplantation revealed the presence of 12 primordial follicles/mm2.
Ovarian Activity (Fig. 2)
The patient continued HT for 8 weeks after surgery. Twelve weeks later (thus 20 weeks after transplantation), vaginal ultrasound revealed the presence of a follicle of 6 mm in the transplantation area. The E2 level was 19 pg/mL and FSH had significantly decreased to 25.6 mIU/mL.
Four weeks later (24 weeks post-transplantation), vaginal
Discussion
This paper reports the first pregnancy to occur after bilateral oophorectomy and ovarian cortex cryopreservation and grafting for benign ovarian pathology (bilateral recurrent abscesses on probable endometriomas). Fertility may indeed be decreased by radical surgery in case of torsion of benign cysts like dermoids or by extensive surgery for endometriomas. Several papers have shown reduced anti-Müllerian hormone levels, a sign of decreased ovarian reserve, after ovarian cystectomy for
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J.D. has nothing to disclose. P.J. has nothing to disclose. C.P. has nothing to disclose. G.H. has nothing to disclose. D.D. has nothing to disclose. J.S. has nothing to disclose. J.S. has nothing to disclose. M.-M.D. has nothing to disclose.
J.D. and P.J. contributed equally to this article.
This work was supported by grants from the Fonds National de la Recherche Scientifique de Belgique (grant nos. 3.4590.08F and 7.4507.10), the Foundation Against Cancer (Belgium), and the Fondation Saint-Luc and donations from A Frère, Ph. de Spoelberch, and P. Ferrero.