Original articlePrediction of in vitro fertilization outcome at different antral follicle count thresholds in a prospective cohort of 1,012 women
Section snippets
Experimental Design
In this prospective, observational study we aimed to recruit all subjects who were undergoing their first cycle of IVF or intracytoplasmic sperm injection (ICSI) treatment. The study was performed at the University of Nottingham's Assisted Conception Unit (Nurture Fertility: Nottingham University Research and Treatment Unit in Reproduction) and included all subjects who met the above criterion between March 2005 and July 2009. Subjects were excluded if they were found to have an ovarian cyst or
Results
A total of 1,120 subjects were recruited. Of these, 27 were excluded owing to the presence of an ovarian cyst(s), leaving 1,093 subjects. Of the 1,030 subjects who subsequently began treatment, 18 failed to down-regulate, leaving 1,012 for the final analysis. The mean ± SD (range) age, body mass index (BMI), basal FSH, AFC, and ovarian volume were 34.3 ± 4.3 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44 years, 24.4 ± 3.5 18, 19, 20, 21, 22, 23, 24, 25
Discussion
This is the first study using a large population to report the probabilities of live birth and the risks of adverse treatment outcome that can occur during ART, based on different thresholds of AFC measured using 3D ultrasound. The data confirm that AFC is a significant predictor of live birth, poor ovarian response, and moderate or severe OHSS. Although AFC offers the best predictive ability for determining poor ovarian response and OHSS among all the conventional ovarian reserve markers
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2021, Reproductive BioMedicine OnlineCitation Excerpt :In addition, this is the first study to analyse the risk factors for hemoperitoneum. The incidences of moderate-to-severe OHSS and severe hemoperitoneum were 1–5% (Jayaprakasan et al., 2012; Kahnberg et al., 2009; Luke et al., 2010; Papanikolaou et al., 2006; Practice Committee of the American Society for Reproductive Medicine, 2016; Steward et al., 2014) and 0.04–0.23%, respectively (Aragona et al., 2011; Bennett et al., 1993; Dicker et al., 1993; Govaerts et al., 1998; Levi-Setti et al., 2018; Liberty et al., 2010; Nouri et al., 2014; Zhen et al., 2010), according to other reports of complications in ART treatment. In Japan, the incidences of moderate-to-severe OHSS and severe hemoperitoneum were 0.79% and 0.08% of ART cycles, respectively, which is either comparable to or less than the incidence in other countries.
K.J. has nothing to disclose. Y.C. has nothing to disclose. R.I. has nothing to disclose. Z.H. has nothing to disclose. J.H. has nothing to disclose. A.C. has nothing to disclose. N.R.-F. has nothing to disclose.
This study was funded by the University of Nottingham.