Serum antimüllerian hormone in response to dietary management and/or physical exercise in overweight/obese women with polycystic ovary syndrome: secondary analysis of a randomized controlled trial
To investigate whether randomized diet and/or physical exercise influence serum levels of antimüllerian hormone (AMH) in obese women with polycystic ovary syndrome (PCOS).
Design
Randomized, 4-month trial with three interventions.
Setting
Women's health clinical research unit at a university hospital.
Patient(s)
Fifty-seven overweight/obese women with PCOS.
Intervention(s)
Diet, physical exercise, or both, using programs individually adapted and supervised by a dietician and/or a physiotherapist.
Main Outcome Measure(s)
Serum AMH levels before and after the interventions and correlations to reproductive function, body composition, and endocrine and metabolic variables.
Result(s)
After intervention, serum levels of AMH were significantly decreased only in the diet group, and the levels were significantly lower than in the exercise group. The strongest predictor of decreased AMH was a decrease in free T, whereas weight loss had no significant influence. Normalized levels of AMH were associated with improvements in menstrual cyclicity and hyperandrogenism but not in metabolic variables.
Conclusion(s)
This randomized study supports that diet reduces serum AMH in association with decreased androgen levels in obese women with PCOS. Increased serum AMH may be used as a marker of ovulatory dysfunction and hyperandrogenism but not as a marker of insulin resistance.
Clinical Trial Registry Number
ISRCTN48342048.
Key Words
AMH
PCOS
obesity
diet
exercise
Cited by (0)
Å.N. has nothing to disclose. K.C. has nothing to disclose. F.F. has nothing to disclose. P.M.H. has nothing to disclose. A.L.H. has nothing to disclose.
This study was supported financially by Swedish Research Council grant 20324 (A.L.H.), the Karolinska Institutet, the Stockholm County Council, and the A. M. Thomér Fund.