Case reportA fatal poisoning with 5-methoxy-N,N-diisopropyltryptamine, Foxy
Introduction
Foxy is a slang name for 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT). It has hallucinogenic properties, similar to other tryptamine compounds. The users of 5-MeO-DIPT experienced euphoria, dilated pupils, empathy, visual and auditory distortions, feelings of love and emotional distress as well as nausea, vomiting and diarrhea [1], [2]. 5-MeO-DIPT was mainly metabolized 5-hydroxy-N,N-diisopropyltryptamine (5-OH-DIPT) and 5-methoxy-N-isopropyltryptamine (5-MeO-NIPT) in human [3].
We shall discuss about the findings at autopsy and the toxicological report following a fatal overdose.
Section snippets
Case history
The decedent (male A) was a 29-year-old male. The male A was a sexual partner of male B, who, in search of his sexual pleasure, injected an aqueous solution of 5-MeO-DIPT into the anus of male A using a dropper in a hotel room at approximately 21:00 h. Following the injection, male A developed abnormal symptoms including very intense agitation and was rushed to hospital. However, he died at about 00:30 h on the following day. Blood and urine specimens were submitted for toxicological examination.
Materials
5-MeO-DIPT was synthesized according to the method of Shulgin and Shulgin [4]. 5-Hydroxy-N,N-diisopropyltryptamine and 5-methoxy-N-isopropyltryptamine were synthesized according to the method of Kamata et al. [3]. All other chemicals and reagents used were of the highest commercially available quality.
Extraction
A 1 ml portion of urine and blood specimens were adjusted to pH 8 with 2.8% ammonium hydroxide and mixed vigorously with two volumes of a chloroform–isopropyl alcohol mixture (3:1, v/v). After
Results and discussion
The recovery from blood of the three compounds, 5-OH-DIPT, 5-MeO-DIPT and 5-MeO-NIPT, was >80%, >55% and >70%, respectively. Good inter and intra-assay precision was also observed (coefficient of variation <10%). The limit of quantification of 5-MeO-DIPT, 5-OH-DIPT and 5-MeO-IPT was 0.01 μg/ml.
Meatherall and Sharma [5] have described a case of 21-year-old a Caucasian male who ingested a pill called Foxy containing an unknown amount of drug. A urine sample was collected approximately 4 h after
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