Original articleClinical endoscopyEUS-guided FNA for the diagnosis of GI stromal cell tumors: sensitivity and cytologic yield
Section snippets
Methods
In this retrospective study, the combined Massachusetts General Hospital (MGH) and Brigham and Women's Hospital (BWH) pathology database was searched for all patients presenting between January 1998 and May 2006 with surgically resected, histologically confirmed, c-kit–positive GISTs. Computerized medical records were reviewed for all patients to determine those who also underwent EUS-guided FNA before surgical removal. Those patients with primary GISTs located in the esophagus, stomach, small
Results
Review of the pathology database yielded 460 patients with surgically resected, histologically confirmed, c-kit–positive GISTs. Of these, 37 patients met inclusion criteria. GISTs were located in the stomach in 32 patients, the duodenum in 3 patients, the esophagus in 1 patient, and the rectum in 1 patient. There were 29 patients with diagnostic FNA cytologic findings (group A), and 8 patients with nondiagnostic cytologic findings (group B). A total of 44.8% (13/29) of patients in group A were
Discussion
GISTs are the most commonly identified intramural, subepithelial mass in the upper GI tract, accounting for approximately 5000 to 6000 new cases each year.6 These masses are frequently found on endoscopy performed for other reasons, but patients may also present with abdominal pain, bleeding, or symptoms of mass effect. Approximately 20% to 25% of gastric and 40% to 50% of small-intestinal GISTs are clinically malignant,3 but it is well recognized that all GISTs have some degree of malignant
Acknowledgments
We thank Shiva Gautam, PhD, for his help in reviewing the statistics in this article.
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2020, Journal of the American Society of CytopathologyCitation Excerpt :Nonetheless, a number of studies also have evaluated the efficacy of EUS-guided FNAB for submucosal and intramural lesions.15-19 Most of these have focused primarily on gastrointestinal stromal tumors (GISTs) because of their higher incidence compared with other mesenchymal lesions in this location.20-32 The objective of our 10-year retrospective study was to evaluate the diagnostic efficacy of EUS-guided FNAB for all mesenchymal neoplasms arising within the tubular gut wall and immediately adjacent tissue.
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DISCLOSURE: The following author disclosed financial relationships relevant to this publication: W. Brugge received an educational grant from Pentax Corporation. All other authors disclosed no financial relationships relevant to this publication.
Presented at Digestive Diseases Week, May 21, 2007, Washington, DC (Gastrointest Endosc 2007;65:AB205).
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