Brief reportImmunoglobulin G4–related inflammatory pseudotumor of the stomach
Section snippets
Case 1
A 59-year-old woman was found to have a hard, fixed, subepithelial lesion during gastroscopy (Fig. 1). An abdominal CT scan revealed a well-defined, solid, enhancing mass. EUS revealed a 3.3 × 1.4–cm, homogeneous, hypoechoic mass arising from echo layer 4 (muscularis propria) of the stomach, suggesting a GI stromal tumor (Fig. 2). The patient underwent laparoscopic wedge resection. Grossly, the specimen was a thickened, fusiform structure that histologically showed a well-demarcated,
Discussion
Recently, many cases of IgG4-related sclerosing disease of organs other than the pancreas have been reported, including IgG4-related inflammatory pseudotumors of the liver1 and lung,2 with or without autoimmune pancreatitis. There are also some reports describing upper GI tract involvement.3, 4, 5
This report describes two cases of IgG4-related inflammatory pseudotumor of the stomach presenting as echo layer 4, hypoechoic, subepithelial tumors. Histopathologically, the major cellular component
Disclosure
All authors disclosed no financial relationships relevant to this publication.
References (5)
- et al.
IgG4-positive plasma cells in inflammatory pseudotumor (plasma cell granuloma) of the lung
Hum Pathol
(2005) - et al.
Autoimmune pancreatitis presenting with IgG4-positive multiple gastric polyps
Gastrointest Endosc
(2010)
Cited by (29)
The protean manifestations of IgG4-RD in gastrointestinal disorders
2015, Disease-a-MonthIgG4-related disease of the ileocecal region mimicking malignancy: A case report
2014, International Journal of Surgery Case ReportsClinicopathological characteristics of gastric IgG4-related disease: Systematic scoping review
2022, Journal of Gastroenterology and Hepatology (Australia)Utility of gastric biopsy in diagnosing IgG4-related gastrointestinal disease
2021, Pathology InternationalCase report of IgG4-related appendiceal disease: A challenging disease
2020, Medicine (United States)