Original articleClinical endoscopyNarrow-band imaging versus white light versus mapping biopsy for gastric intestinal metaplasia: a prospective blinded trial
Section snippets
Patients
Patients were enrolled at the Los Angeles County University of Southern California Medical Center from September 2014 to May 2016, and the study was registered at Clinicaltrials.gov (NCT02197351). Written informed consent and Health Insurance Portability and Accountability Act authorization were obtained from all patients before enrollment. All authors had access to the study data and approved the final submission.
Patients undergoing upper endoscopy for standard clinical care for the following
Patients
Given the transition of our endoscopy unit from the Evis Exera II 180 series upper endoscopes to a newer system with different NBI capabilities, the study was halted after 112 patients were enrolled. The mean age was 51.9 ± 10.6 years, and 63% were female (Table 1). One hundred patients (89%) were Hispanic, 7 (6%) were Asian, and 5 (5%) were black or white. Eight patients were born in the United States (7%); the remainder originated from Mexico (63%), Central America (24%), and Asia (6%). One
Discussion
In this prospective blinded trial, we demonstrated that targeted biopsies guided by NBI or mapping biopsies had a per-patient yield more than 2-fold greater than that of targeted biopsies guided by HD-WL. Because NBI-guided biopsies and updated Sydney mapping protocol biopsies identified different patients and sites, our data suggest that these methods are best used in combination in the evaluation of patients at increased risk for gastric cancer because of country of origin and ethnicity.
Prior
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DISCLOSURE: J. Buxbaum is a consultant for Olympus. All other authors disclosed no financial relationships relevant to this publication.
If you would like to chat with an author of this article, you may contact Dr Buxbaum at [email protected].