Original articleClinical endoscopyComparison of endoscopy and radiographic imaging for detection of esophageal inflammation and remodeling in adults with eosinophilic esophagitis
Section snippets
Study design
This study examined a retrospective cohort of patients with EoE who presented between 2001 and 2014 at a single academic medical center. Patients were identified via review of a prospectively maintained EoE patient database. The study was approved by the institutional review board at Northwestern University.
Study population
Patients included fulfilled the 2011 EoE consensus recommendation criteria for EoE.1 All patients undergoing EGD and UGI over the study period were identified. Patients were included if the
Patient characteristics
Seventy patients fit inclusion criteria for analysis, with basic demographics outlined in Table 3. There was a male predominance and a mean age of 40 years and median age of 37 years. Some 63% had an atopic phenotype defined by the presence of asthma, allergic rhinitis, atopic dermatitis, or food allergy. Characteristics of EGD and UGI studies are detailed in Table 1. Most UGI studies were performed for dysphagia without a known diagnosis (n = 41, 59%), and approximately half (n = 36, 51%) were
Discussion
The diagnostic and therapeutic assessment of EoE currently relies on symptom reporting and histologic evaluation. Neither radiologic imaging nor endoscopic findings are required for the diagnosis or treatment monitoring, although both modalities provide the means of assessing esophageal remodeling.9, 10 Prior studies have demonstrated the importance of remodeling consequences in the risk of food impaction in EoE.9, 11 In the current study we demonstrated similar detection rates for overall
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DISCLOSURE: The following author disclosed financial relationships relevant to this publication: I. Hirano: Consultant and research support recipient from Shire, Regeneron, Receptos, and Adare. All other authors disclosed no financial relationships relevant to this publication.