Letter to the Editor
Outcomes of pharmacogenetics-guided dosing of warfarin: A systematic review and meta-analysis

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  • Clinical benefits of pharmacogenetic algorithm-based warfarin dosing: Meta-analysis of randomized controlled trials

    2015, Thrombosis Research
    Citation Excerpt :

    However, the more important end points, the rates of bleeding and thrombotic complications, were still beyond the power design of these trials [19]. Recent published meta-analyses explored the effects of genotype-based warfarin dosing on clinical outcomes [20–24], which provided valuable, however in certain circumstances also conflicting results. Thus, whether PG algorithm-based strategy in patients initiating anticoagulant therapy with warfarin lead to more precise dosing and, by extrapolation, reduce the risk of thrombotic and bleeding complications is still in controversy.

  • Oral anticoagulation: A critique of recent advances and controversies

    2015, Trends in Pharmacological Sciences
    Citation Excerpt :

    These studies have employed different inclusion and exclusion criteria and thus have included different numbers of trials and patients. Consequently the findings have also been discordant: while Franchini et al. [55] and Tang et al. [57] reported that genotype guided-dosing had some benefits, the other two [56,58] failed to show a difference between control and genotype dosing arms. Although the meta-analyses have used the heterogeneity statistic I2 as a measure of heterogeneity, arguably in the context of complex algorithms which differ considerably from one another, this is not an adequate measure for evaluating the heterogeneity.

  • Warfarin dosing algorithms: A systematic review

    2021, British Journal of Clinical Pharmacology
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