CorrespondenceConversion of persistent atrial fibrillation to sinus rhythm after LAA ligation with the LARIAT device
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Conflict of interest
R.J. Lee is a consultant and equity holder in SentreHEART, Inc. S. Mittal is a consultant to SentreHEART, Inc.
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Cited by (17)
The Strengths and Weaknesses of Left Atrial Appendage Ligation or Exclusion (LARIAT, AtriaClip, Surgical Suture)
2023, Cardiac Electrophysiology ClinicsThe Strengths and Weaknesses of Left Atrial Appendage Ligation or Exclusion (LARIAT, AtriaClip, Surgical Suture)
2022, Interventional Cardiology ClinicsCitation Excerpt :Because the LAA undergoes necrosis and atrophy after LAA ligation,56,57 the electrical isolation of the LAA is permanent. Direct effects of electrical isolation of the LAA arise from observations of termination of atrial tachycardias originating from the LAA,89,90 spontaneous conversion to sinus rhythm in cohort of patients with persistent or longstanding persistent AF who underwent LAA ligation for prevention of LAA thrombus formation,91 and a decrease in AF burden in patients with cardiac implantable electronic devices who underwent successful LAA exclusion.92 LAA ligation produces a debulking of the LA with significant beneficial electrical remodeling.60–62
Concomitant epicardial left atrial appendage ligation and left atrial ablation of atrial fibrillation: Safety, feasibility and outcome
2021, Indian Pacing and Electrophysiology JournalSubxiphoid Hybrid Epicardial-Endocardial Atrial Fibrillation Ablation and LAA Ligation: Initial Sub-X Hybrid MAZE Registry Results
2020, JACC: Clinical ElectrophysiologyCitation Excerpt :The rationale to emulate the surgical Cox-maze III procedure is the observation that substrate beyond the PVs may contribute to triggers and maintenance of persistent and LSP AF. Recent observational studies have demonstrated the increased efficacy of freedom from AF with LAA isolation and LAPWI (21–25). LAA ligation produces electric isolation of the LAA and LA debulking, resulting in the elimination of potential LAA triggers and electric remodeling of the left atrium (21–23,26–28).
Left Atrial Appendage Electrical Isolation as a Target in Atrial Fibrillation
2019, JACC: Clinical ElectrophysiologyCitation Excerpt :In another study, AF burden (baseline: 76%) following the Lariat procedure in patients with continuous monitoring of AF with cardiac implantable electronic devices was found to be lower (3 months: 42%; p < 0.0001) compared with baseline (76%) with reduced but sustained effect at 12-month follow-up (12 months: 59%, p < 0.001) (48). In another study further highlighting the importance of the LAA (49), 8% of patients with persistent AF converted to normal sinus rhythm following LAA ligation. The effect of the Lariat device in reduction of AF recurrence may also be multifactorial and not limited to its achievement of LAAEI.
Combination of Left Atrial Appendage Isolation and Ligation to Treat Nonresponders of Pulmonary Vein Isolation
2018, JACC: Clinical ElectrophysiologyCitation Excerpt :The durability of WLAAI in this study was comparable to the above-mentioned 22.6% of the patients showing LAA reconnection. LAA exclusion via ligation with the LARIAT device itself can isolate the LAA and therefore help to maintain both a durable LAA isolation and stable SR in AF patients (14,19–22). We observed repeat WLAAI after LAA ligation in 2 patients with LAA reconnection.
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R.J. Lee is a consultant and equity holder in SentreHEART, Inc. S. Mittal is a consultant to SentreHEART, Inc.