Sex differences in acute myocardial infarction: Is it only the age?☆
Section snippets
Methods
Our data come from the DIAMANTE (Descripción del Infarto Agudo de Miocardio: Actuaciones, Novedades, Terapias y Evolución—Description of Acute Myocardial Infarction: Management, New Therapies and Evolution) database. This database includes prospectively collected consecutive patients with STEMI admitted to the Coronary Intensive Care Unit of the Gregorio Marañon General Hospital (Madrid, Spain), a primary PCI-capable tertiary centre offering service “24/7”, between January 2010 and April 2015.
Results
The registry included 1111 patients (258 women; 23.2%). Mean age was 64.1 ± 14.0 years. The proportion of women increased with age (from 14.7% in the first quartile [< 53 years] to 40.4% in those in the last one [> 76]). Nine patients were missing at 30 days of follow-up (0.8%), and long-term follow-up data could not be recorded in 22 patients (2.0%). Mean follow-up was 23.8 ± 19.4 months.
Baseline characteristics according to sex are shown in Table 1A, Table 1B. Mean age in women was 8 years higher than
Discussion
Our study confirms that in patients with STEMI, women have higher unadjusted in-hospital and long-term mortality than men. However, this difference is mainly due to age. In fact, the differences in mortality between men and women disappeared only by performing age adjustment.
In the first 30 days, major adverse events were more frequent in women than in men, but women presented more frequently with cardiovascular risk factors (except smoking) and a more severe clinical presentation; factors that
Funding support
This work was partially supported by the Red de Investigación Cardiovascular (RiC), Instituto de Salud Carlos III, Madrid, Spain, grant number RD120042/0001. The sponsor had no role in the study.
Conflict of interest
None. All authors have approved the final article.
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All authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.