Clinical Paper
Head and Neck Oncology
Analysis of efficacy and safety of core-needle biopsy versus fine-needle aspiration cytology in patients with cervical lymphadenopathy and salivary gland tumour

https://doi.org/10.1016/j.ijom.2018.04.003Get rights and content

Abstract

In this study, we compared the diagnostic accuracy and safety of fine-needle aspiration cytology and core-needle biopsy in patients with cervical lymphadenopathy or salivary gland tumour, and provided a basis for selecting the appropriate diagnostic method in clinical situations. A total of 278 patients were included in this study. The sensitivities of fine-needle aspiration cytology and core-needle biopsy were 66.7% and 100%, respectively, and negative predictive values were 92.6% and 100%, respectively, for diagnosing malignancy. In diagnosing lymphoma, fine-needle aspiration cytology gave false-negative results in all patients. In diagnosing tuberculous lymphadenopathy, the sensitivities of fine-needle aspiration cytology and core-needle biopsy were 33.3% and 91.15%, respectively, and the negative predictive values were 90.0% and 95.1%, respectively. The sensitivities of fine-needle aspiration cytology and core-needle biopsy were 42.9% and 100% in diagnosing malignant salivary gland tumours, and the negative predictive values were 91% and 100%, respectively. The results of this study showed that core-needle biopsy was superior in diagnosing and distinguishing critical diseases such as malignant lymphadenopathy and tuberculosis in patients with cervical lymphadenopathy and salivary gland tumour.

Section snippets

Materials and methods

This retrospective study was conducted at a tertiary medical institution and was approved by the Institutional Review Board of Korea University. The medical records of patients with cervical lymphadenopathy or salivary gland tumour who visited Korea University Guro Hospital from January 2005 to December 2015 were reviewed. As CNB presents technical difficulties in paediatric patients, only patients aged 15 years or older were enrolled in the study. Only patients with at least 2 years of follow-up

Results

A total of 278 patients were included in this study. To confirm the disease, 112 patients underwent FNAB as an initial diagnostic method, and 166 underwent CNB. Gender and age did not differ significantly between the FNAC and CNB groups. Lesion location and final diagnosis differed significantly. Table 1 summarizes other clinical information.

During the study period, 184 patients presented with cervical lymphadenopathy. Of these, 62 patients underwent FNAC as an initial diagnostic method (Fig. 1

Discussion

FNAC plays an important role in diagnosing cervical lymphadenopathy and salivary gland tumour. Because a thin needle is used to draw specimens for histologic examination, FNAC is easy to perform and more tolerable. Physicians can use the cytologic results of FNAC to distinguish critical diseases, including malignant tumours and tuberculosis, from benign tumours or self-limiting inflammatory diseases. FNAC provides important clues to diagnose disease or select the next procedure to confirm the

Funding

None.

Ethical approval

This study was approved by Institutional Review Board of Korea University (2011-11-0026).

Patient consent

Not required.

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© 2018 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.