Transdermal delivery of vitamin K using dissolving microneedles for the prevention of vitamin K deficiency bleeding
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Graphical abstract
Abbreviations
FTIR
Fourier Transform Infrared Spectroscopy
ICH
International Conference on Harmonisation of Technical Requirements for Pharmaceuticals for Human Use
IM
intramuscular
LEDC
less economically developed country
LoD
limit of detection
LoQ
limit of quantification
MN
microneedle
OCT
optical coherence tomography
PVP
polyvinylpyrrolidone
RH
relative humidity
UK
United Kingdom
UV
ultraviolet
VKDB
vitamin K deficiency bleeding
Keywords
Dissolving microneedles (MN)
Less economically developed countries (LEDCs)
Transdermal drug delivery
Vitamin K
Vitamin K deficiency bleeding (VKDB)
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© 2018 The Authors. Published by Elsevier B.V.