International Journal of Radiation Oncology*Biology*Physics
Volume 60, Issue 4, 15 November 2004, Pages 1013-1015
EditorialFractionation and late rectal toxicity
References (41)
- et al.
Late GI and GU complications in the treatment of prostate cancer
Int J Radiat Oncol Biol Phys
(1997) - et al.
Late rectal toxicity after conformal radiotherapy of prostate cancer (I)Multivariate analysis and dose-response
Int J Radiat Oncol Biol Phys
(2000) - et al.
Interim report of toxicity from 3D conformal radiation therapy (3D-CRT) for prostate cancer on 3DOG/RTOG 9406, level III (79.2 Gy)
Int J Radiat Oncol Biol Phys
(2002) - et al.
Preliminary evaluation of low-grade toxicity with conformal radiation therapy for prostate cancer on RTOG 9406 dose levels I and II
Int J Radiat Oncol Biol Phys
(2003) - et al.
Hazards of dose escalation in prostate cancer radiotherapy
Int J Radiat Oncol Biol Phys
(2003) - et al.
High-dose intensity modulated radiation therapy for prostate cancerEarly toxicity and biochemical outcome in 772 patients
Int J Radiat Oncol Biol Phys
(2002) - et al.
The prediction of late rectal complications in patients treated with high dose-rate brachytherapy for carcinoma of the cervix
Int J Radiat Oncol Biol Phys
(1997) - et al.
Rectal bleeding and its management after irradiation for uterine cervical cancer
Int J Radiat Oncol Biol Phys
(2004) - et al.
The correlation of acute toxicity and late rectal injury in radiotherapy for cervical carcinomaEvidence suggestive of consequential late effect (CQLE)
Int J Radiat Oncol Biol Phys
(1998) - et al.
Consequential late effects in normal tissues
Radiother Oncol
(2001)
Relationship between acute and late normal tissue injury after postoperative radiotherapy in endometrial cancer
Int J Radiat Oncol Biol Phys
(2002)
Radiation tolerance of the rat rectum to fractionated X-rays and pi-mesons
Radiother Oncol
(1988)
The effect of cis-diamminedichloroplatinum(II) on radiation damage in mouse rectum after fractionated irradiation
Radiother Oncol
(1989)
Early and late injuries in mouse rectum after fractionated X-ray and neutron irradiation
Radiother Oncol
(1993)
Chronic radiation damage in the rat rectumAn analysis of the influences of fractionation, time and volume
Radiother Oncol
(1994)
Sublethal damage repair times for a late-responding tissue relevant to brachytherapy (and external-beam radiotherapy)Implications for new brachytherapy protocols
Int J Radiat Oncol Biol Phys
(1998)
Hypofractionation for prostate cancer radiotherapy—what are the issues?
Int J Radiat Oncol Biol Phys
(2003)
Diabetes mellitusA predictor for late radiation morbidity
Int J Radiat Oncol Biol Phys
(1999)
Late morbidity profiles in prostate cancer patients treated to 79–84 Gy by a simple four-field coplanar beam arrangement
Int J Radiat Oncol Biol Phys
(2003)
Dose escalation with 3D-CRT in prostate cancerFrench study of dose escalation with conformal 3D radiotherapy in prostate cancer—preliminary results
Int J Radiat Oncol Biol Phys
(2000)
Cited by (172)
The Fraction Size Sensitivity of Late Genitourinary Toxicity: Analysis of Alpha/Beta (α/β) Ratios in the CHHiP Trial
2023, International Journal of Radiation Oncology Biology PhysicsHow Low Can You Go? The Radiobiology of Hypofractionation
2022, Clinical OncologyEstimates of Alpha/Beta (α/β) Ratios for Individual Late Rectal Toxicity Endpoints: An Analysis of the CHHiP Trial
2021, International Journal of Radiation Oncology Biology PhysicsCitation Excerpt :These EQD2-corrected comparisons of regimens are dependent on an accurate estimate of the α/β ratio. Researchers have previously provided human estimates for the α/β ratio of overall late rectal toxicity in the range 2.7 to 7.2 Gy.18-21 However, individual rectal toxicity endpoints (eg, bleeding, urgency) are driven by different upstream pathophysiologic processes22 and may thus have distinct sensitivity to fraction size, as manifest by the α/β ratio.
Copyright © 2004 Elsevier Inc. All rights reserved.