Editorial
Fractionation and late rectal toxicity

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  • Cited by (172)

    • Estimates of Alpha/Beta (α/β) Ratios for Individual Late Rectal Toxicity Endpoints: An Analysis of the CHHiP Trial

      2021, International Journal of Radiation Oncology Biology Physics
      Citation Excerpt :

      These EQD2-corrected comparisons of regimens are dependent on an accurate estimate of the α/β ratio. Researchers have previously provided human estimates for the α/β ratio of overall late rectal toxicity in the range 2.7 to 7.2 Gy.18-21 However, individual rectal toxicity endpoints (eg, bleeding, urgency) are driven by different upstream pathophysiologic processes22 and may thus have distinct sensitivity to fraction size, as manifest by the α/β ratio.

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