International Journal of Radiation Oncology*Biology*Physics
Poster Viewing AbstractPreliminary Results of Re-irradiation for Locally Recurrent Nasopharyngeal Carcinoma with Intensity Modulated Radiotherapy
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Purpose/Objective(s)
To evaluate the treatment outcome and radiation toxicity in patients with locally recurrent nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiation therapy (IMRT).
Materials/Methods
From Jun 2006 to January 2009,53 patients with locally recurrent NPC received re-irradiation using IMRT. The rT classification distribution was 13 for rT1,2 for rT2,16 for rT3 and 22 for rT4. N1 and N2 disease was found in 12 (8 for N1, 4 for N2) patients. The number of patients with Stage I, IIa-b, III, IVa disease was 9, 4, 18, and 22, respectively. Median time from initial radiotherapy to the nasopharyngeal recurrence was 55 months. All patients were treated with 6MV photon with 7-9 fields.
Results
Ninety-six percent of GTV received 95% of the prescribed dose (V95-GTV).The dose encompassing 95% of GTV (D95-GTV) was 67.9 Gy. The average dose covered of GTV was 66.7Gy. The doses of surrounding critical structures were lower than the tolerable thresholds. After re-irradiation, 74% patients had complete response of primary tumor. Twenty six percent of patients had partial response. One-year and 2-year overall survival and progression-free survival rates were 71.7%, 69.8% and
Conclusions
Our preliminary results showed that IMRT is feasible for patients with recurrent NPC. High dose IMRT may result in radio-necrosis of nasopharyngeal mucosa and bleeding. The hemorrhage was the main death cause. The incidence of serious toxicities was relatively low. More patients and longer term follow-up are warranted to evaluate late toxicities and treatment outcome.
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Author Disclosure: J. Zhou, None; H. Ying, None; C. Hu, None; X. He, None; G. Zhu, None; Y. Wu, None; X. Wang, None.