In the bilateral ITA scenario, the skeletonization has a protective effect against SWI.
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Diabetic patients benefit more from the skeletonization than the non-diabetic ones.
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The meta-regression identified no modulating factors influencing the results.
Abstract
Background: It is suggested that the internal thoracic artery (ITA) harvesting technique influences the incidence of sternal wound infection (SWI) after coronary artery bypass graft (CABG) surgery when both right and left ITAs are used. We conducted a meta-analysis to determine whether there is any difference between skeletonized versus pedicled bilateral ITA in terms of SWI after CABG. Methods: We performed a systematic-review using MEDLINE, EMBASE, CENTRAL/CCTR, SciELO, LILACS, Google Scholar and reference lists of relevant articles to search for studies that compared the incidence of SWI after CABG between skeletonized versus pedicled bilateral ITA until May 2014. The principal summary measures were odds ratio (OR) with 95% Confidence Interval (CI) and P values (statistically significant when <0.05). The ORs were combined across studies using weighted DerSimonian–Laird random effects model. Meta-analysis, sensitivity analysis and meta-regression were carried out by using the software Comprehensive Meta-Analysis version 2 (Biostat Inc., Englewood, New Jersey). Results: Eight studies involving 2633 patients (1698 skeletonized; 935 pedicled) met the eligibility criteria. There was no evidence for important heterogeneity of the effects among the studies. The overall OR (95% CI) of SWI showed statistical significant difference in favor to skeletonized ITA (random effect model: OR 0.327; 95% CI 0.217–0.492; P < 0.001). In sensitivity analysis, the difference in favor to skeletonized ITA was observed mainly in the presence of diabetes. In meta-regression, we observed no modulation of the effects. Conclusion: When both ITAs are used, the skeletonized technique appears to reduce the incidence of SWI after CABG in comparison to the pedicled technique.
