Elsevier

International Journal of Surgery

Volume 13, January 2015, Pages 245-249
International Journal of Surgery

Original research
The extent of improvement of health-related quality of life as assessed by the SF36 and Paseika scales after parathyroidectomy in patients with primary hyperparathyroidism – A systematic review and meta-analysis

https://doi.org/10.1016/j.ijsu.2014.12.004Get rights and content
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Highlights

  • Parathyroidectomy for PHPT potentially improves function and quality of life.

  • However, there is no quantitative evidence to support this for all studies.

  • Provides evidence that parathyroidectomy improves the quality of life of PHPT patients.

Abstract

Background: Previous studies have shown that parathyroidectomy for primary hyperparathyroidism (PHPT) improve the function and quality of life of patients. The aim of this systematic review and meta-analysis is to determine the health-related quality of life outcomes among those having surgical management for PHPT. Methods: Several databases were searched (MEDLINE, EMBASE, PubMed, Current Contents) for studies in which health-related quality of life was measured by reliable and validated instruments (SF-36 and Paseika Questionnaire) before and after parathyroidectomy for patients with primary hyperparathyroidism (PHPT). For the SF-36, score differences greater than 5 points indicate clinically relevant changes. Results: There were six studies with quality of life data. The SF-36 data was derived from 238 patients, with a mean age of 59 years and 71% were females. The range of follow up after surgery was 6 months to one year. The pre- and post-parathyroidectomy SF-36 quality of life scale scores were vitality (44 vs. 60, p < 0.001), physical functioning (51 vs. 69, p < 0.001), bodily pain (50 vs. 65, p < 0.001), general health (54 vs. 64, p < 0.001), role physical (34 vs. 52, p < 0.001), role emotional (43 vs. 59, p < 0.001), role social (60 vs. 74, p < 0.001), and mental health (55 vs. 71, p < 0.001). The Paseika data was derived from 203 patients, with a mean age of 54 years and 67% were females. The pre- and post-parathyroidectomy Paseika scores were feeling tired (51 vs. 19, p < 0.001), feeling thirsty (29 vs. 12, p < 0.001), mood swings (33 vs. 12, p < 0.001), joint pains (32 vs. 14, p < 0.001), irritability (31 vs. 10, p < 0.001), feeling blue (31 vs. 14, p < 0.001), feeling weak (37 vs. 15, p < 0.001), itchy (17 vs. 7, p < 0.001), forgetful (27 vs. 16, p < 0.001), headache (18 vs. 5, p < 0.001), abdominal pain (19 vs. 8, p < 0.001), bone pain (38 vs. 17, p < 0.001), ability to move off chair (27 vs. 11, p < 0.001). Conclusion: Parathyroidectomy significantly improves the short to medium-term health-related quality of life of patients suffering from primary hyperparathyroidism.

Keywords

Health-related quality of life
Parathyroidectomy
Primary hyperparathyroidism
Meta-analysis

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