Immunity
Volume 32, Issue 1, 29 January 2010, Pages 67-78
ArticleThe mTOR Kinase Determines Effector versus Memory CD8+ T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin
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Highlights
► mTOR kinase activity regulates naive CD8+ T cell differentiation ► mTOR activity is essential for T-bet mediated effector functions ► Blockade of mTOR activity promotes Eomesodermin expression and memory generation ► Rapamycin treated memory CD8+ T cells show greater tumor efficacy than effector cells
MOLIMMUNO
CELLIMMUNO
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