Immunity
Volume 36, Issue 2, 24 February 2012, Pages 239-250
ArticleSuppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity
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Graphical Abstract
Highlights
► SOCS3 inhibits the catalytic activities of JAK1, JAK2, and TYK2 but not JAK3 ► A three-residue motif specific to JAK kinases is crucial for its interaction with SOCS3 ► SOCS3 binds JAK and cytokine receptor simultaneously ► SOCS3 is a noncompetitive JAK inhibitor
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These authors contributed equally to this work
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Present address: Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia
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