Journal of the American Academy of Dermatology
Case ReportCutaneous lymphatic malformations in disappearing bone (Gorham-Stout) disease: A novel clue to the pathogenesis of a rare syndrome
Section snippets
Case report
A 21-year-old man with a 7-year history of cutaneous lymphatic malformations of the left lower extremity was hospitalized for diffuse pain in the left leg secondary to a recent minor trauma. There was no personal or family history of systemic vascular processes, and no associated constitutional symptoms were observed. Without a definite diagnosis being made, he developed difficulty in walking and severe progresssive bone pain in the left leg, exacerbated by physical activity. One year after his
Discussion
Gorham-Stout disease, also known as disappearing bone disease, vanishing bone, or phantom bone, is a rare syndrome belonging to the primary idiopathic osteolyses. First described in 1838 by Jackson,1 who reported the case of a young man with a progressively disappearing humerus, the syndrome became known as Gorham-Stout disease in 1955, when their review of 16 cases was published in the Journal of Bone and Joint Surgery.2 The syndrome may occur in any bone, but common sites include the long
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Funding sources: None.
Conflicts of interest: None identified.