Case ReportTreatment of a patient with epidermodysplasia verruciformis carrying a novel EVER2 mutation with imiquimod
Section snippets
Case report
A 22-year-old Hispanic man had a 10-year history of flat warts on the face, chest, and extremities and a 6-month history of a rapidly growing mass on the mid upper aspect of his chest. The patient had worked as a painter for 5 years and spent the majority of his time outdoors. He denied previous radiation or chemical exposure other than paint and chemicals associated with his job. There was no family history of similar skin lesions or skin cancer. His parents were nonconsanguineous and grew up
Discussion
EV is a rare autosomal recessive HPV-associated genodermatosis characterized by development of disseminated flat warts and widespread pityriasis versicolor-like and seborrheic keratosis-like plaques that start in early childhood on the back of hands, extremities, and face and spread to involve larger areas.1 A pseudo-Koebner's phenomenon is frequently observed in affected patients, with multiple flat warts appearing in excoriated areas as a result of inoculation of HPV. It is usually regarded
References (18)
- et al.
Applying nonsense-mediated mRNA decay research to the clinic: progress and challenges
Trends Mol Med
(2006) - et al.
Imiquimob 5% cream in the treatment of Bowen's disease
J Am Acad Dermatol
(2001) - et al.
Treatment of epidermodysplasia verruciformis with a combination of acitretin and interferon alfa-2a
J Am Acad Dermatol
(2001) - et al.
No apparent effect of cidofovir in epidermodysplasia verruciformis
J Clin Virol
(2000) - et al.
Epidermodysplasia verruciformis
South Med J
(2003) - et al.
Nomenclature for the description of human sequence variations
Hum Genet
(2001) - et al.
Ein Fall einer bisher nicht beschriebenen Hauterkrankungn (Epidermodysplasia verruciformis)
Arch Dermatol Syphilol
(1922) - et al.
Nested PCR approach for detection and typing of epidermodysplasia verruciformis-associated human papillomavirus types in cutaneous cancers from renal transplant recipients
J Clin Microbiol
(1995) - et al.
Epidermodysplasia verruciformis defines a subset of cutaneous human papillomaviruses
J Virol
(2001)
Cited by (47)
Acitretin Treatment Improves a Case of Severe Generalized Epidermodysplasia Verruciformis
2024, Mayo Clinic ProceedingsMonogenic etiologies of persistent human papillomavirus infections: A comprehensive systematic review
2024, Genetics in MedicineCommon Presentations and Diagnostic Approaches
2014, Stiehm's Immune DeficienciesEpidermodysplasia verruciformis
2013, Piel
Dr Berthelot is currently affiliated with the Department of Internal Medicine, University of Texas Health Science Center at Houston.
Funding sources: None.
Disclosure: Drs Tyring and Pandya are consultants, are clinical researchers, and serve on the speakers' bureau for 3M Pharmaceuticals, maker of imiquimod. Drs Berthelot, Dickerson, Rady, He, and Niroomand have no conflicts of interest to declare.
Presented in poster form at the American Academy of Dermatology 65th Annual Meeting, Washington, DC, February 2-6, 2007.
Reprints not available from the authors.