Journal of the American Academy of Dermatology
A comparison of postprocedural wound care treatments: Do antibiotic-based ointments improve outcomes?
Section snippets
Methods
This 4-week, double-blind, multicenter trial enrolled men and women with Fitzpatrick skin types I, II, or III. All subjects were required to have two SK located on opposite sides of the front of their chest or abdomen 6 to 10 mm in size. Subjects with any disease state or inappropriate physical skin condition that might impair evaluations or increase the individual’s health risk or with any known allergy or sensitivity to test materials were excluded.
Selected SK sites were cleaned with alcohol,
Results
A total of 30 subjects aged 50 to 83 years (mean, 61 years) completed this study. All participants were Caucasian with Fitzpatrick skin type I (26.7%), II (63.3%), or III (10.0%). The majority of study participants were female (76.7%).
Clinical grading assessment showed no differences between wounds treated with AHO versus Poly/Bac for the wound-healing parameters of erythema, edema, epithelial confluence, crusting, and scabbing at any time point (Fig 1).
For the subjective irritation
Discussion
This study demonstrated that equivalent healing of wounds was achieved using an antibiotic-free ointment compared with an antibiotic-based topical ointment. AHO and Poly/Bac treatment resulted in equivalent healing for all clinical and subjective irritation parameters. This was not unexpected, as both products have a similar petrolatum base, which provides a protective moist environment that facilitates re-epithelialization and wound healing. Petrolatum is classified by the Food and Drug
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Publication of this article was supported by Beiersdorf Inc.
Disclosure: Dr Draelos has been a consultant for Beiersdorf Inc, Merz Pharmaceuticals, and Johnson & Johnson. Dr Rizer has been a consultant for Johnson & Johnson. Dr Trookman is a consultant for Thomas J. Stephens & Associates.