Original articleWhen does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council
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Drs Irvine and Paller contributed equally to this article.
Corporate sponsorship was provided to the International Eczema Council by Abbvie, Amgen, Celgene, Chugai, Galderma, GlaxoSmithKline/Stiefel, the Leo Foundation, Leo Pharma, Lilly, MedImmune/Astrazeneca, Pfizer, Sanofi, Genzyme and Regeneron Pharmaceuticals, and Valeant. The sponsors had no influence on the content and viewpoints in this article. The cost of publication was covered by the International Eczema Council.
Disclosure: Dr Simpson is an investigator for GlaxoSmithKline, Novartis, Regeneron, Vanda, and Tioga and a consultant with honorarium for Celgene, Galderma, Dermira, Genentech, GlaxoSmithKline, Pfizer, Regeneron, and Sanofi. Dr Bruin-Weller is an investigator for Roche and an investigator and consultant for Abbvie and Regeneron/Sanofi, with all fees paid to her institution. Dr Flohr is a consultant with honorarium for Roche/Genentech and Sanofi/Regeneron. Dr Barbarot is a consultant with honorarium for Pierre Fabre Laboratory and Sanofi-Genzyme, a speaker/educator with honorarium for Bioderma, and an investigator with Pierre Fabre Laboratory. Dr Deleuran is an investigator for AbbVie and Sanofi Genzyme and a consultant with honorarium for CKCare Foundation, La Roche Posay, Leo Pharma, Meda Pharma, Pierre Fabre, Regeneron, and Sanofi Genzyme. Dr Bieber is an investigator or consultant or lecturer for Sanofi, Regeneron, Novartis, Roche, Astellas, Galderma, Pfizer/Anacor, GlaxoSmithKline, Lilly, and L′Oréal. Dr Cork is a consultant with honorarium and investigator for Regeneron and Sanofi. Dr Drucker is a consultant with honorarium for Astellas Canada, Prime Inc, Sanofi, and Spire Learning and an investigator for Sanofi and Regeneron. Dr Eichenfield is a consultant with honorarium for Anacor/Pfizer, Galderma, Genentech, Lilly, Regeneron/Sanofi, and Valeant and an investigator for Regeneron/Sanofi. Dr Foelster-Holst is an investigator (with fees paid to her institution) for Astellas, Novartis Pharma, Phamanet, Pierre Fabre, and Regeneron and a consultant with honoraria for ALK/Abbott, Ardeypharm, Astellas, Johnson and Johnson, La Roche Posay, and Neubourg Skin care GMBH and Co. Dr Guttman is a consultant with honorarium for AbbVie, Allergan, Amgen, Anacor, Bristol-Myers Squibb, Celgene, Celsus Therapeutics, Dermira, Drais, Eli Lilly, Escalier, Galderma, Genentech, Glenmark, LEO Pharma, Mitsubushi Tanabe, Novartis, Pfizer, Regeneron, Sanofi, Stiefel/GlaxoSmithKline, and Vitae and principal investigator for Bristol-Myers Squibb, Celgene, Dermira, Janssen Biotech, LEO Pharma, Merck, Novartis, and Regeneron. Dr Nosbaum is a consultant with honorarium for Sanofi. Dr Reynolds is an investigator for BBSRC Case with AstraZeneca, Stiefel/GlaxoSmithKline, Bristol Myers Squib, Genentech, Innovate UK with Stiefel/GlaxoSmithKline, and Wellcome Trust/GlaxoSmithKline and a consultant with honorarium for Genentech. Dr Schmitt is an investigator for ALK, Merck Sharp and Dohme, Novartis, Pfizer, and Sanofi and a consultant with honorarium for Novartis and Roche. Dr Spuls is a consultant with honorarium for AbbVie, Anacor, Leo Pharma, and Novartis and an investigator for Leopharma and Schering Plough; she reports also having been involved in performing clinical trials with many pharmaceutical industries that manufacture drugs used for the treatment of psoriasis and atopic dermatitis. Dr Thyssen is a consultant with honorarium for Leo Pharma, Roche, and Sanofi-Genzyme. Dr Wollenberg is a consultant with honorium for Almiral, Anacor, Astellas, Bioderma, Celgene, Chugai (travel grant), Galderma, Hans Karrer, Leo Pharma, L'Oreal, MEDA, MedImmune, Merck Sharp and Dohme, Novartis, Pierre Fabre, Pfizer, Regeneron, and Sanofi-Adventis and he received research funding from Beiersdorf and Leo Pharma. Dr Irvine is a consultant with honorarium for AbbVie, Anacor, Chugai Pharma, Genentech, and Sanofi Regeneron. Dr Paller is a consultant with honorarium Anacor, Eli Lilly, Galderma, GlaxoSmithKline/Stiefel, Pierre Fabre, Puricore, Regeneron/Sanofi, Roivant, and Valeant and an investigator for Astellas and Pfizer. Drs Ardern-Jones, Vestergaard, Brown, Silverberg, Seyger, Stalder, Su, Takaoka, Traidl-Hoffmann, and Van der Schaft have no conflicts of interest to declare.
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