Continuing medical educationNeutrophilic dermatoses: Pyoderma gangrenosum and other bowel- and arthritis-associated neutrophilic dermatoses
Section snippets
Epidemiology
Key points Pyoderma gangrenosum is a rare inflammatory skin disease Pyoderma gangrenosum is more common in females than in males Approximately 50% of cases have associated medical comorbidities
Pyoderma gangrenosum (PG) is a rare inflammatory skin disease with an estimated incidence of 3 to 10 cases per million people per year.1 It affects individuals of all ages but is most common in adults between 40 and 60 years of age, with an average age of onset of 44 years.2, 3 It is more common in females versus
Bowel-associated dermatosis-arthritis syndrome
Key points Bowel-associated dermatosis-arthritis syndrome is most commonly seen in patients who have undergone bowel bypass surgery or other gastrointestinal surgeries with a blind-loop, as well as patients with a history of IBD Patients classically present with a constellation of symptoms resembling serum sickness, including myalgias, arthritis, and an inflammatory skin eruption The pathogenesis is thought to involve intestinal bacteria overgrowth and subsequent immune complex formation Treatment includes
Conclusion
In conclusion, NDs are a heterogeneous group of inflammatory skin disorders that are unified by the presence of sterile, predominantly neutrophilic infiltrates on histopathology. NDs are often associated with underlying infectious, inflammatory, and neoplastic disorders or medications. The available evidence points to altered expression of inflammatory effector molecules, abnormal neutrophil function, and genetic predisposition in the pathogenesis of these disorders. Treatment often involves
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Skin disorders and interstitial lung disease: Part II—The spectrum of cutaneous diseases with lung disease association
2023, Journal of the American Academy of DermatologyAutoinflammation: Interferonopathies and Other Autoinflammatory Diseases
2022, Journal of Investigative DermatologyCitation Excerpt :Other dermatological diseases with overlapping autoinflammation include contact dermatitis, which is dependent on innate immunity for disease development (Gans et al., 2020). NDs are a heterogeneous group of disorders widely associated with monogenic AIDs (Ashchyan et al., 2018). A number of cytokines observed in AIDs have been implicated in the pathogenesis of neutrophilic dermatoses, including IL-1, IL-8, IL-17, and TNF-α (Marzano et al., 2014; McGonagle and McDermott, 2006; Nelson et al., 2018).
Neutrophilic dermatoses
2022, Medicine (Spain)Clinical, epidemiological, and therapeutic hallmarks of pyoderma gangrenosum: a case series of 35 patients
2024, International Journal of DermatologyBehandlung der Acne fulminans mit Tumornekrosefaktor-α-Inhibitoren – eine Übersicht klinischer Fälle und der Literatur: Tumor necrosis factor-α inhibitor treatment of acne fulminans – a clinical and literature review
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Date of release: December 2018
Expiration date: December 2021
Supported by a private donation from Mr Jerry and Mrs Joan Berstein.
Conflicts of interest: None disclosed.