State-of-the-Art PaperCyclic Guanosine Monophosphate Signaling and Phosphodiesterase-5 Inhibitors in Cardioprotection
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Key Words
cGMP
cardiomyocytes
infarction
ischemia
signaling
Abbreviations and Acronyms
ANP
atrial natriuretic peptide
BNP
B-type natriuretic peptide
cAMP
cyclic adenosine monophosphate
cGMP
cyclic guanosine monophosphate
DOX
doxorubicin
DMD
Duchenne muscular dystrophy
GC
guanylyl cyclase
I/R
ischemia-reperfusion
mdx
dystrophin-deficient
MI
myocardial infarction
mitoKATP
mitochondrial KATP
NO
nitric oxide
NOS
nitric oxide synthase
NP
natriuretic peptide
PDE
phosphodiesterase
pGC
particulate guanylyl cyclase
PKG
cyclic guanosine monophosphate–dependent protein kinases
sGC
soluble guanylyl cyclase
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This study was supported by grants from the National Institutes of Health (HL51045, HL79424, and HL93685) to Dr. Kukreja and a National Scientist Development Grant from the American Heart Association (10SDG3770011) to Dr. Salloum. The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.