Clinical ResearchCardiometabolic RiskEffect of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease: A Mendelian Randomization Analysis
Cardiometabolic Risk
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Key Words
cardiovascular disease
genetic polymorphism
low-density lipoprotein cholesterol
myocardial infarction
prevention
Abbreviations and Acronyms
CHD
coronary heart disease
HDL-C
high-density lipoprotein cholesterol
LDL-C
low-density lipoprotein cholesterol
MI
myocardial infarction
OR
odds ratio
SNP
single-nucleotide polymorphism
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Funded by Wayne State University School of Medicine. Dr. Flack is a consultant to Novartis, Medtronic, Back Beat Hypertension, Boehringer Ingleheim, and Daiichi Sankyo; and has received research grants from Novartis, Medtronic, and the NIH. Dr. Williams is a consultant and speaker for Astellas Healthcare, Inc. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.