Original InvestigationEffect of Naturally Random Allocation to Lower Low-Density Lipoprotein Cholesterol on the Risk of Coronary Heart Disease Mediated by Polymorphisms in NPC1L1, HMGCR, or Both: A 2 × 2 Factorial Mendelian Randomization Study
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Key Words
ezetimibe
genetic association
PCSK9
statins
Abbreviations and Acronyms
CHD
coronary heart disease
HMGCR
3-hydroxy-3-methylglutaryl-coenzyme A reductase
LDL-C
low-density lipoprotein cholesterol
MI
myocardial infarction
NPC1L1
Niemann-Pick C1-Like 1
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This research was funded in part by an investigator-initiated grant from Merck & Co. The funding body had no role in the design, conduct, or analysis of the study; did not have access to any of the data; did not participate in drafting of the manuscript; and did not participate in the decision to submit for publication.
Dr. Ference has reported significant research grants, modest service as a consultant and advisory board member, and has received modest honoraria from Merck. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.