The Present and FutureState-of-the-Art ReviewLong Noncoding RNAs: From Clinical Genetics to Therapeutic Targets?
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Key Words
cardiac
long noncoding RNA
microRNA
vascular
Abbreviations and Acronyms
ANRIL
antisense noncoding RNA in the INK4 locus
APF
autophagy-promoting factor
Bvht
Braveheart
CAD
coronary artery disease
CARL
cardiac-apoptosis related long noncoding RNA
Cas9
CRISPR-associated protein 9
CDKN2B
cyclin-dependent kinase inhibitor 2B
CHRF
cardiac hypertrophy related factor
circRNA
circular RNA
CRISPR
clustered regularly interspaced short palindromic repeats
GWAS
genome-wide association studies
lncRNA
long noncoding RNA
MALAT1
metastasis-associated lung adenocarcinoma transcript 1
MDRL
mitochondrial dynamic related long noncoding RNA
Mhrt
myosin heavy chain-associated RNA transcript
MIAT
myocardial RNA transcript
miRNA
micro–RNA
mRNA
messenger RNA
NFIA
nuclear factor IA
PRC1
polycomb repressive complex 1
PRC2
polycomb repressive complex 2
SENCR
smooth muscle and endothelial cell-enriched migration/differentiation-associated long noncoding RNA
shRNA
small hairpin RNA
siRNA
small interfering RNA
SNP
single-nucleotide polymorphism
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Drs. Boon, Jaé, and Dimmeler have filed for a patent regarding long noncoding RNAs in cardiovascular disease. Dr. Holdt has reported that she has no relationships relevant to the contents of this paper to disclose.
Copyright © 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.