Original InvestigationPlasma Trimethylamine N-Oxide, a Gut Microbe–Generated Phosphatidylcholine Metabolite, Is Associated With Atherosclerotic Burden
Key Words
Abbreviations and Acronyms
Cited by (0)
This research was supported by grants from the National Institutes of Health (NIH) and the Office of Dietary Supplements (R01HL103866, P20HL113452, R01DK106000). The BioBank study has been supported by NIH grants P01HL076491, P01HL098055, R01HL103931, and the Cleveland Clinic Clinical Research Unit of the Case Western Reserve University CTSA (UL1TR 000439). Mass spectrometry studies were performed on instruments housed in a facility supported in part by a Center of Innovations Award by AB SCIEX. High-sensitivity cardiac troponin T testing reagents were provided by Roche Diagnostics. Dr. Wang was partially supported by NIH grant R01HL130819. Dr. Hazen was partially supported by a gift from the Leonard Krieger endowment.
Drs. Wang, Levison, and Hazen are named as co-inventors on pending patents held by the Cleveland Clinic relating to cardiovascular diagnostics and therapeutics. Drs. Levison and Wang have received royalty payment for inventions or discoveries related to cardiovascular diagnostics from Cleveland Heart Lab. Dr. Hazen is a paid consultant for Esperion and P&G; has received research funds from Abbott, P&G, Pfizer Inc., Roche Diagnostics, and Takeda; and has received royalty payments for inventions or discoveries related to cardiovascular diagnostics or therapeutics from Cleveland Heart Lab, Siemens, Esperion, and Frantz Biomarkers, LLC. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.