Special section: Food allergyLoss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy
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S.J.B. is supported by a Wellcome Trust Intermediate Clinical Fellowship (ref 086398/Z/08/Z). Y.A. is supported by a Canadian Institutes of Health Research fellowship, an AllerGen CAIDATI training award, and Bruce Katz Travel Fund and Canadian Dermatology Foundation Frederick Kalz bursaries. H.J.C. is supported by a Wellcome Trust Senior Fellowship (ref 087436). The food allergy assessment of the ALSPAC cohort was supported by the United Kingdom Food Standards Agency (project T07001). M.B.-S. is supported by the AllerGen Network of Centres of Excellence. The Canadian peanut allergy case collection and controls were supported by grants from the Canadian Dermatology Foundation, the University of Saskatchewan, Department of Medicine Research Fund, and the Foundations of the McGill University Health Centre and the Montreal Children’s Hospital as well as grants from the Canadian Allergy, Asthma, and Immunology Foundation and the AllerGen Network of Centres of Excellence. A.C. is a National Research Scholar of the Fonds de la recherche en sante de Quebec. J.O'B.H. is supported by the National Children’s Research Centre, Dublin. A.D.I. is supported by the National Children’s Research Centre, Dublin, and the Wellcome Trust. Filaggrin research in the McLean laboratory is supported by grants from the British Skin Foundation, National Eczema Society, Medical Research Council (ref G0700314), the Wellcome Trust (ref 090066/B/09/Z and 092530/Z/10/Z), and donations from anonymous families affected by eczema in the Tayside Region of Scotland.
Disclosure of potential conflict of interest: W. H. I. McLean has filed patents on genetic testing and therapy development aimed at the filaggrin gene. The rest of the authors have declared that they have no conflict of interest.
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These authors contributed equally to this work.