Mechanisms of allergy and clinical immunologyIL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization
Section snippets
Methods
Supplemental information can be found in the Methods section in this article’s Online Repository at www.jacionline.org.
Airway sensitization to HDM does not require TSLP signaling
We sought to investigate the requirement of TSLP in experimental allergic asthma to the clinically relevant allergen HDM. This model23 solely involves mucosal exposure, does not use any exogenous adjuvant, and critically requires the canonical TH2-inducing molecule IL-4.24 Consistent with a previous report,25 TSLP was detected in the lungs of naive mice, and levels were increased upon 3-day HDM exposure (Fig 1, A), a protocol that induces sensitization without overt inflammation. TSLP
Discussion
It has been increasingly recognized that TH2 immunity results from adaptive immune responses that are shaped by initial innate signals. Among these, epithelium-associated cytokines, such as TSLP, IL-25, and IL-33, have been the subject of intense investigation. Here we investigated the initiation of allergic asthma and food allergy using models involving 2 clinically relevant allergens and different mucosal sites and sensitization strategies. We show that the development of HDM and peanut
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Supported by CIHR, Anaphylaxis Canada, and grants from MedImmune LLC. D.K.C. is a CIHR Vanier Scholar. A.L.-G. is supported by a Fundación Caja Madrid doctoral scholarship (Spain). J.E.B. holds an NSERC Doctoral Canada Graduate Scholarship. M.J. holds a Senior Canada Research Chair in Immunobiology of Respiratory Diseases and Allergy.
Disclosure of potential conflict of interest: S. Waserman has received research support from Anaphylaxis Canada and is employed by McMaster University. A. J. Coyle was an employee of MedImmune LLC and is now an employee of Pfizer. R. Kolbeck is employed by and has stock options in MedImmune LLC. A. A. Humbles is employed by MedImmune LLC and has stock options in MedImmune (AZ). M. Jordana has received research support from MedImmune LLC, Anaphylaxis Canada, and the Canadian Institutes of Health Research and is employed by McMaster University. The rest of the authors declare that they have no relevant conflicts of interest.
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These authors contributed equally to this work.
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Jeanette E. Boudreau, PhD, is currently affiliated with the Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY.