Asthma and lower airway diseaseBody mass index trajectory classes and incident asthma in childhood: Results from 8 European Birth Cohorts—a Global Allergy and Asthma European Network initiative
Section snippets
Study design and population
Inclusion criteria for the present analyses were anthropometric measurement of weight and length at birth with at least 3 follow-ups over the first 6 years of life and reported asthma diagnosis for at least 2 follow-ups. In addition, data on age at each measurement for both weight and height and asthma diagnosis needed to be available.
The number of infants at birth and at each measurement period with anthropometric measurements of weight and height are listed in Table I for each analyzed birth
Results
The average BMI-SDS and its SD at birth and for each follow-up year for each study and separated for boys and girls seem to be, with some exceptions (AMICS-Barcelona at years 1, 3, 4, and 6 for boys; AMICS-Menorca at years 3 and 4 for boys; and GINIplus at birth), rather homogenous across the cohorts (Table II).18, 19
The percentage of incident asthma events is 4.1% in the first 2 years of life and 2.8% and 2.5% in the time periods of 3 to 4 years and 5 to 6 years, respectively.
Estimates of
Discussion
Children with a rapid BMI-SDS gain in the first 2 years of life (BMI-SDS trajectory classes 3 and 2) had a higher risk for asthma incidence within the first 6 years of life than children with a less pronounced weight gain slope in childhood (BMI-SDS trajectory class 1). For children with a persistent rapid BMI-SDS gain from birth up to age 6 years (class 3), this effect on incident asthma was similar but not statistically significant, even without adjustment for sex, birth weight,
References (50)
- et al.
Overweight: no association with asthma or bronchial reactivity in children
J Allergy Clin Immunol
(2009) - et al.
Overweight and changes in weight status during childhood in relation to asthma symptoms at 8 years of age
J Allergy Clin Immunol
(2009) - et al.
Higher adiposity in infancy associated with recurrent wheeze in a prospective cohort of children
J Allergy Clin Immunol
(2008) - et al.
Wheezing and asthma in childhood: an epidemiology approach
Allergol Immunopathol (Madr)
(2008) Obesity and asthma
Paediatr Respir Rev
(2006)- et al.
Paediatric asthma and obesity
Paediatr Respir Rev
(2006) - et al.
Longitudinal study on cat allergen exposure and the development of allergy in young children
J Allergy Clin Immunol
(2007) - et al.
Adiposity, asthma, and airway inflammation
J Allergy Clin Immunol
(2007) - et al.
Leptin, adiponectin, and asthma: findings from a population-based cohort study
Ann Allergy Asthma Immunol
(2009) - et al.
Obesity and asthma
Pharmacol Ther
(2006)
Joint effects of birth outcomes and childhood body mass index on respiratory symptoms
Eur Respir J
Early childhood weight status in relation to asthma development in high-risk children
J Allergy Clin Immunol
Asthma and obesity: common early-life influences in the inception of disease
J Allergy Clin Immunol
Childhood adiposity predicts adult-onset current asthma in females: a 25-yr prospective study
Eur Respir J
Increased incidence of asthmalike symptoms in girls who become overweight or obese during the school years
Am J Respir Crit Care Med
Obesity and the risk of newly diagnosed asthma in school-age children
Am J Epidemiol
Body-mass index as a predictor of incident asthma in a prospective cohort of children
Pediatr Pulmonol
Sex differences in the relation between body mass index and asthma and atopy in a birth cohort
Am J Respir Crit Care Med
Increasing body mass index from age 5 to 14 years predicts asthma among adolescents: evidence from a birth cohort study
Int J Obes (Lond)
Boys with high body masses have an increased risk of developing asthma: findings from the National Longitudinal Survey of Youth (NLSY)
Int J Obes (Lond)
Obesity and asthma
J Investig Allergol Clin Immunol
A meta-analysis of the effect of high weight on asthma
Arch Dis Child
European birth cohort studies on asthma and atopic diseases: II. Comparison of outcomes and exposures—a GA2LEN initiative
Allergy
European birth cohort studies on asthma and atopic diseases: I. Comparison of study designs—a GALEN initiative
Allergy
Development of a WHO growth reference for school-aged children and adolescents
Bull World Health Organ
Cited by (122)
Airway epithelial development and function: A key player in asthma pathogenesis?
2023, Paediatric Respiratory ReviewsEarly-Life Weight Status and Risk of Childhood Asthma or Recurrent Wheeze in Preterm and Term Offspring
2023, Journal of Allergy and Clinical Immunology: In PracticeIn utero exposure to perfluoroalkyl substances and early childhood BMI trajectories: A mediation analysis with neonatal metabolic profiles
2023, Science of the Total EnvironmentEarly-life weight gain is associated with non-atopic asthma in childhood
2022, World Allergy Organization JournalCitation Excerpt :However, several studies have ignored the distinction between atopic and non-atopic asthma even though these phenotypes may have distinct causal mechanisms. Although previous studies have reported the association of early-life growth patterns with childhood asthma,10–15 it remains unclear whether early-life excess weight gain is associated with atopic or non-atopic asthma. In the present study, we aimed to investigate the temporal association of early-life weight gain with atopic or non-atopic asthma among Asian children in the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren (LIGHTS) cohort.
Persistent overweight or obesity, lung function, and asthma exacerbations in Puerto Rican youth
2022, Annals of Allergy, Asthma and ImmunologyAssociation of Growth Trajectory Profiles with Asthma Development in Infants Hospitalized with Bronchiolitis
2022, Journal of Allergy and Clinical Immunology: In Practice
Supported by the Global Allergy and Asthma European Network (GA2LEN) under the Sixth Framework Programme for Research of the European Union (project no. FOOD-CT-2004-506378) and the “Kompetenznetz Adipositas (Competence Network Obesity)” funded by the Federal Ministry of Education and Research of Germany (FKZ: 01GI0826). Personal and financial support was provided by the Munich Center of Health Sciences (MCHEALTH) as part of the Munich Ludwigs-Maximilians-Universität LMU innovative is gratefully acknowledged. Each of the 8 analyzed birth cohorts had their own funding. The GINIplus study was funded for 3 years by grants of the Federal Ministry for Education, Science, Research, and Technology (Grant No. 01 EE 9401-4), and the 6-year follow-up of the GINIplus study was partly funded by the Federal Ministry of Environment (IUF, FKZ 20462296). The LISAplus study was funded by grants of the Federal Ministry for Education, Science, Research, and Technology (Grant No. 01 EG 9705/2 and 01EG9732), and the 6-year follow-up of the LISAplus study was partly funded by the Federal Ministry of Environment (IUF, FKS 20462296). The MAS study was funded by grants from the German Federal Ministry of Education and Research (BMBF; reference nos. 07015633, 07 ALE 27, 01EE9405/5, 01EE9406) and the German Research Foundation (DFG; reference no. KE 1462/2-1). The DARC study was funded by Danish National Ministry of Health. The PIAMA-NHS study received funding from The Netherlands Organization for Health Research and Development; The Netherlands Organization for Scientific Research; The Netherlands Asthma Fund, The Netherlands Ministry of Spatial Planning Housing, and the Environment; and The Netherlands Ministry of Health, Welfare, and Sport. PIPO was funded by the Research Foundation Flanders (FWO, Fonds Wetenschappelijk Onderzoek Vlaanderen) and by the Ministry of Health of the Flemish Community. The AMICS-Barcelona study was funded by Fondo de Investigación Sanitaria, ISCIII, Ministero de Sanidad y Servicios Sociales, Spain (FIS 95/0314, FIS 96/0799, FIS 00/0021, FIS 03/0296), Istituto Superiore di Sanitá, CIRT-1999 SGR 00241, COLT Foundation and the Fifth European Program (QLK4-CT-2000-00263). The AMICS-Menorca study was funded by Fondo de Investigación Sanitaria, ISCIII, Ministerio de Sanidad y Servicios Sociales, Spain (grants G03/176, CB06/02/0041, 97/0588, 00/0021-2, PI061756 and PS0901958), EC contract no. QLK4-CT-2000-00263 and Fundacion Roger Torne.
Disclosure of potential conflict of interest: T. Keil has received grants from and is employed by Charité Berlin. The rest of the authors declare that they have no relevant conflicts of interest.
- ∗
For a list of study group members, see this article’s Online Repository at www.jacionline.org.