Environmental and occupational diseaseMaternal house dust mite exposure during pregnancy enhances severity of house dust mite–induced asthma in murine offspring
Section snippets
Methods
For a complete description of the materials and methods used in the murine and in vitro experiments, please see the Methods section in this article's Online Repository at www.jacionline.org
Maternal exposure to HDM allergen exacerbates asthma in offspring
Given that prenatal exposures to environmental stimuli can influence offspring asthma, and HDM sensitization is a powerful risk factor for asthma development, we sought to determine whether maternal exposure to HDM during pregnancy impacted offspring asthma. Female A/J mice (a strain that develops severe AHR associated with a mixed TH2/TH17 response43, 44) were exposed to 20 μg HDM extract on days 0, 4, and 10 of pregnancy to ensure a strong HDM-specific immune response was ongoing during
Discussion
Herein, we demonstrate that prenatal exposure to the relevant human aeroallergen, HDM, in the absence of powerful TH2-skewing adjuvants, is sufficient to exacerbate the development of HDM-driven allergic asthma in offspring later in life. Specifically, offspring of allergen-exposed mothers demonstrated more robust AHR and airway inflammation. The increased phenotypic measures of asthma were associated with a greater capacity for TH2 cytokine production and frequency of CD4+IL-13+ cells in the
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This study was funded by the National Institute of Environmental Health Sciences (grant no. P30 ES006096 to I.P.L.), the National Heart, Lung, and Blood Institute (grant no. R01 HL122300 to I.P.L.), the Cincinnati Children's Hospital Medical Center Perinatal Infection and Inflammation Collaborative (C.A.C. and I.P.L.), and the National Institute of Allergy and Infectious Diseases (grant no. R21 AI119385 to I.P.L.).
Disclosure of potential conflict of interest: C. A. Chougnet receives grant support from the National Institutes of Health (NIH) and Buroughts-Wellcome and is a section editor for the Journal of Immunology. I. P. Lewkowich receives grant support from the NIH; serves as a consultant for Janssen Pharmaceuticals; and received travel support from Autumn Immunology Conference Executive Council Meeting. The rest of the authors declare that they have no relevant conflicts of interest.