ReviewValidation studies of the Edinburgh Postnatal Depression Scale for the antenatal period
Introduction
Antenatal major depressive disorder is a major health problem with a prevalence ranging from 3.1% to 4.9%. Taken together with the minor forms of the illness the point prevalence rises to 8.5–11.0% during pregnancy (Gaynes et al., 2005, Kuijpens et al., 2001). It is therefore essential that we have a tool to detect this illness effectively in those at risk. The Edinburgh Postnatal Depression Scale (EPDS), a 10-item self-rating scale, was developed by Cox et al. (1987), originally to detect postnatal depression. The EPDS was constructed from the Snaith׳s Irritability, Depression and Anxiety Scale (Snaith et al., 1978) and the Hospital Anxiety and Depression Scale (Zigmond and Snaith, 1983) in addition to items formulated by the constructors (Cox et al., 1987).
Antenatal depression (AND) often remains unnoticed by health professionals, although it could be detected using self-report scales which are economical and do not require extensive rater training. The EPDS is the most widely used screening instrument perinatally, and it has also been validated in a non-gestational context showing good psychometric properties amongst men (Matthey et al., 2001), infertile women (Peterson et al., 2006), in the perimenopausal period (Becht et al., 2001), and in women who were not pregnant, apart from its original context, post-partum (Cox et al., 1996). Without trying to be exhaustive, the question as to whether the EPDS is a uni- or multidimensional scale has also been studied in both perinatal and non-gestational contexts with Pop et al. (1992), Töreki et al. (2014) and Adouard et al. (2005) identifying 2 dimensions, whereas Bergink et al. (2011) and de Cock et al. (2011) reaching a conclusion of unidimensionality. Before use, a scale devised in another culture, needs to go through cultural validation in order to ensure it is suitable for use in the target population. However, as pointed out by Matthey et al. (2006), the EPDS has often been used, without proper validation, during pregnancy for screening out probable depressive cases with a cut-off defined through a postnatal validation procedure (Kim et al., 2008, Lommatzsch et al., 2006, Doornbos et al., 2009, Schulte-Herbrüggen et al., 2007, de Tychey et al., 2005, Otake et al., 2014, Koutra et al., 2013). Furthermore, it seems that different validation sessions are needed for each trimester of the pregnancy (Bergink et al., 2011, Su et al., 2007, Bunevicius et al., 2009a), suggested by different cut-offs found in three validation studies during the course of pregnancy (Bergink et al., 2011, Su et al., 2007, Bunevicius et al., 2009a). Consequently, it could be methodologically incorrect to recruit women for the validation of the EPDS both before and after giving birth (Tran et al., 2011, Hanlon et al., 2008, Werrett and Clifford, 2006, Areias et al., 1996), that is, to validate the scale in a perinatal sample. The EPDS, with its items retained, has been renamed as the Edinburgh Depression Scale (EDS), to take into consideration its new use in the antenatal period.
Recent studies have repeatedly shown that mental health problems during pregnancy (e.g., depression or anxiety) are associated with impaired obstetric and neonatal outcomes, although some studies found no correlation (Choi et al., 2014, Räisänen et al., 2014). Antenatal stress and depression, for example, have been linked to preterm birth and impaired physical health (Dayan et al., 2006, Suri et al., 2007, Rahman et al., 2004), as well as to future emotional, behavioral, and cognitive problems in the child (Talge et al., 2007, Deave et al., 2008, O’Connor et al., 2002). Although we have little direct evidence available so far to prove that the treatment of perinatal depression improves obstetric outcome (Engelstad et al., 2014, Lindqvist et al., 2014) or good quality evidence that depression screening improves depression outcome (Thombs and Stewart, 2014), there is enough evidence to suggest that maternal depression is linked to poor maternal and infant health outcomes that argues in favor of improving routine screening during pregnancy.
Early screening for antenatal depression is recommended by some national professional bodies, such as the UK׳s National Institute for Health and Clinical Excellence (NICE, 2007) (“Antenatal and postnatal mental health: clinical management and service guidance”). Therefore, there is a well-defined and expressed need for an easy-to-administer self-report scale that can be used by healthcare professionals, such as midwives, obstetricians, health visitors, and family doctors.
There is a disagreement around whether pregnancy is a risk or a protective factor for mood disorders (Bergink et al., 2011, Cox et al., 1996, Töreki et al., 2013, Töreki et al., 2014). Having a cross-culturally valid screening instrument would be very helpful in settling this question.
Investigators using the EPDS to screen for depression should realize that the instrument does not exclusively measure depression but anxiety too (Brouwers et al., 2001, Matthey et al., 2013). This, however, is more of an added benefit rather than a problem, as anxiety disorders, when discovered, can also be effectively treated.
A large review study (Gibson et al., 2009) has previously been published on the validity of the EPDS in both ante- and postnatal depressions; however that review could only include three antenatal studies. Since the publication of the Gibson review (Gibson et al., 2009), four more antenatal studies (Töreki et al., 2014, Bergink et al., 2011, Rubertsson et al., 2011, Stewart et al., 2013, Wang et al., 2009) have been published and the conclusions from these highlight the need for making appropriate recommendations in the light of the newly published material.
The primary objective of this study was to identify all published antenatal validation studies on the EPDS and to present their design along with the estimated sensitivity, specificity and positive and negative predictive values. An additional aim was to estimate the 95% confidence intervals of the screening values on the basis of the sample sizes and detected depression cases in each study. In addition, we assessed the association between the prevalence of antenatal depression and the estimates of the positive and negative predictive values of the Edinburgh Postnatal Depression Scale and the interrelation between the true and false positive rates of validation studies.
Section snippets
Search strategy
Previous validation studies of the EPDS during pregnancy in the English-language literature were identified through the MEDLINE, EMBASE, ISI, CINAHL, SCIELO, Cochrane Library and PsyCINFO databases from 1987 onwards, when the EPDS was launched, until December 2013, using the following search terms: ‘Edinburgh Postnatal Depression Scale’ OR ‘EPDS’ OR ‘scale’ OR ‘tool’ OR ‘inventory’ OR ‘questionnaire’ AND ‘valid?’ OR ‘screen’ OR ‘Diagnos?’ OR ‘semi?structured’ OR ‘interview’ OR ‘Valid’ OR
Search results
The search strategy identified 11 EPDS validation studies in the antenatal period (Bunevicius et al., 2009a, Su et al., 2007, Felice et al., 2006, Adewuya et al., 2006, Bergink et al., 2011, Adouard et al., 2005, Murray and Cox, 1990, Wang et al., 2009, Rubertsson et al., 2011, Stewart et al., 2013, Töreki et al., 2014), reporting that the EPDS was a valid screening instrument for depressive disorders during pregnancy in 11 different countries. The reference lists in these publications did not
Discussion
It is not advisable to use universal cut-off scores, as there can be cultural differences and/or differences in how successful the adaptation of the EPDS was in a given culture, resulting in differences in at what total score the best trade-off between sensitivity and specificity can be found.
There is a painful lack of a systematic review on the prevalence of major depressive disorder in each trimester. Trimester-specific EPDS validation studies are urgently needed in each culture instead of
Limitations
This systematic review has confirmed that the screening accuracy of the EPDS in diagnosing depression during pregnancy is satisfactory and that the EPDS can be recommended for use for this purpose. The heterogeneity of included studies prevented progression to meta-analysis and further statistical comparison of the EPDS across settings was not possible.
Role of funding source
Nothing declared.
Conflict of interest
None of the authors has a political, personal, intellectual, commercial, financial or religious conflict of interest, and/or other relation to manufacturers of pharmaceuticals, laboratory supplies and/or medical devices or to commercial providers of medically related services.
Acknowledgment
None.
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