Original scientific articlePlasma D-Dimer Levels Show Correlation with Number of Lymph Node Metastases in Patients with Esophageal Cancer
Section snippets
Patients
Between January 2002 and December 2004, a total of 193 patients with esophageal cancer underwent esophagectomy with lymphadenectomy at the Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases. From this group, 96 were enrolled in this study, based on the following criteria: patients were primary cases and had received no earlier treatment, such as chemotherapy or radiotherapy. Curative resection was considered potentially possible by preoperative examinations.
Results
Clinicopathologic characteristics of the 96 patients, mostly men (88 of 96), are summarized in Table 1. From a histologic viewpoint, squamous cell carcinoma was predominant (89 of 96). Preoperative plasma DD, SCC-Ag, and CEA levels were compared among the subgroups of patients with various clinicopathologic characteristics (Table 2). There were no significant differences in the plasma DD levels based on gender, age, tumor location, tumor size, or the histologic type of the tumor. Plasma DD
Discussion
Hemostatic and fibrinolytic abnormalities have been reported to be correlated with tumor progression in various malignancies, including lung cancer, colorectal cancer, ovarian cancer, cervical cancer of the uterus, and prostate cancer.2, 3, 8, 9, 20, 21 Among the many hemostasis and fibrinolysis parameters, DD, a degradation product of fibrin, has recently attracted the attention of researchers in this field. Several studies reported that plasma DD levels can predict disease progression and
References (40)
- et al.
Haemostatic abnormalities in lung cancerprognostic implications
Eur J Cancer
(1997) - et al.
Cancer and thrombosis revisited
Blood Rev
(2001) - et al.
Extrinsic-pathway activation in cancer with high factor VIIa and tissue factor
Lancet
(1995) - et al.
Alteration of coagulation and fibrinolysis systems after multidrug anticancer therapy for lung cancer
Eur J Cancer
(1994) - et al.
Phase II study of docetaxel plus enoxaparin in chemotherapy-naive patients with metastatic non-small cell lung cancerpreliminary results
Lung Cancer
(2003) - et al.
Clinicopathologic factors correlated with number of metastatic lymph nodes in oesophageal cancer
Dig Liver Dis
(2001) - et al.
Staging of esophageal cancercomputed tomography, magnetic resonance imaging, and endoscopic ultrasound
Semin Roentgenol
(1994) - et al.
Prognostic significance of blood coagulation tests in lung cancer
Eur Respir J
(2001) Coagulation abnormalities in malignancya review
Semin Thromb Hemost
(1992)
Molecular basis for the relationship between thrombosis and cancer. Thromb
Res
Rates of initial and recurrent thromboembolic disease among patients with malignancy versus those without malignancy. Risk analysis using Medicare claims data
Medicine (Baltimore)
Activation of coagulation and fibrinolysis in patients with lung cancerrelation to tumour stage and prognosis
Blood Coagul Fibrinolysis
Effect of warfarin anticoagulation on survival in carcinoma of the lung, colon, head and neck, and prostate. Final report of VA Cooperative Study #75
Cancer
Subcutaneous heparin treatment increases survival in small cell lung cancer
Cancer
Clotting factors in tumor tissueimplications for cancer therapy
Blood Coagul Fibrinolysis
Plasma levels of D-dimer in lung carcinomaclinical and prognostic significance
Cancer
Relationship between plasma D-dimer levels and clinicopathologic parameters in resectable colorectal cancer patients
World J Gastroenterol
Circulating D-dimer levels are better predictors of overall survival and disease progression than carcinoembryonic antigen levels in patients with metastatic colorectal carcinoma
Cancer
Plasma fibrin D-dimer levels correlate with tumour volume, progression rate and survival in patients with metastatic breast cancer
Br J Cancer
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Competing Interests Declared: None.