ReviewLack of association of TLR4 polymorphisms with susceptibility to rheumatoid arthritis and ankylosing spondylitis: A meta-analysis
Section snippets
1 Introduction
Rheumatoid arthritis (RA) is an autoimmune disease, characterized by chronic inflammation in synovial joints. It ranges in severity from mild arthritis to severe systemic disease affecting internal organs [1]. Human leukocyte antigen (HLA), the major genetic susceptibility locus, has been demonstrated with susceptibility to RA, but HLA is considered to contribute less than one-third of the total genetic susceptibility component [2], [3], [4], and other non-HLA genes might contribute to RA
2.1 Identification of eligible studies and data extraction
All of the studies discussing the relationship between TLR4 D299G/T399I and RA/AS were fully considered and carefully selected in November 2011. A search of the literature was made using MedLine and PubMed to identify available articles, references in the studies were reviewed to find additional studies not indexed by MedLine or PubMed, with the text words “toll-like receptor 4”, “TLR4”, “rheumatoid arthritis”, “RA”, “ankylosing spondylitis”, “AS” and “polymorphism”. We only recruited data from
Studies included in the meta-analysis
Characteristics of studies investigating the association of TLR4 D299G/T399I polymorphisms with RA/AS were present in Table 2. A total of eleven relevant studies met the inclusion criteria were identified, including RA: D299G (six studies), T399I (three studies); AS: D299G (five studies), T399I (four studies) [5], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]. Because of not enough samples to ethnicity-specific, stratified analysis based on ethnicity was not done for allele and
Discussion
As is known, there is individual susceptibility to autoimmune diseases even with the same environmental exposure. Host factors, including gene polymorphisms involved in autoimmune diseases, might have interpreted this difference partly. Therefore, genetic susceptibility to autoimmune diseases has been a research focus in the scientific community. Recently, genetic variants of the TLR4 gene in the pathogenesis of some autoimmune diseases have fascinated much attention. Studies have suggested that
Disclosure of interest
The authors declare that they have no conflicts of interest concerning this article.
Acknowledgement
This work was partly supported by grants from the key program of National Natural Science Foundation of China (30830089) and the Anhui Provincial Natural Science Foundation (11040606M183).
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Wang-Dong and Shan-Shan Liu contributed equally to this work and should be considered co-first authors.