Elsevier

Joint Bone Spine

Volume 80, Issue 1, January 2013, Pages 109-110
Joint Bone Spine

Letter to the editor
Macrophage activation syndrome revealing disseminated tuberculosis in a patient on infliximab

https://doi.org/10.1016/j.jbspin.2012.06.022Get rights and content

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Disclosure of interest

The authors declare that they have no conflicts of interest concerning this article.

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  • Infection is the major trigger of hemophagocytic syndrome in adult patients treated with biological therapies

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    A retrospective diagnosis of HLH associated with systemic M. tuberculosis infection mimicking a catastrophic antiphospholipid syndrome in a patient treated with infliximab was made. We identified 30 patients who developed HLH after administration of biological therapy: 29 from the PubMed search and the unpublished case previously detailed (Tables 1 and 2) [11–39]. One of the 30 patients had already-diagnosed HLH but experienced a flair/worsening of HLH after administration of biological therapy (case 25).

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