Depression and anxiety in adolescents and adults with cystic fibrosis in the UK: A cross-sectional study

doi:10.1016/j.jcf.2014.02.010

Journal of Cystic Fibrosis

Volume 13, Issue 6, December 2014, Pages 745-753

https://doi.org/10.1016/j.jcf.2014.02.010 Get rights and content

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Abstract

Background

The International Depression/anxiety Epidemiological Study (TIDES) in the UK aimed: (i) to establish the prevalence of anxiety and depression amongst people with CF compared to a normative sample; (ii) to establish the association between mood, demographic and clinical variables; and (iii) to provide guidance for specialist-referral decision-making.

Methods

Patients (≥ 12 years) completed the Hospital Anxiety and Depression Scale (HADS). CF-HADS scores, expressed as percentiles, were compared with a normative sample. Multiple-regression analysis explored associations between demographic, clinical and mood variables.

Results

Thirty-nine CF centres recruited 2065 patients. Adults with CF were similar in terms of anxiety and depression to the general population. Adolescents with CF were less anxious and depressed. For adult patients, older age, unemployment for health reasons and poor lung function were associated with disordered mood. Gender-specific CF-percentile scores were calculated.

Conclusion

Surveillance, with attention to gender and risk factors is advocated. This work provides unique benchmark scores to aid referral decision-making.

Keywords

Anxiety

Depression

HADS

Cystic fibrosis

Prevalence

Management

Cited by (0)

¹: TIDES-UK Group (Ruth Easby, Addenbrooke's Hospital; Jenny Cottrell, Alder Hey Children's NHS Trust; Judy Bradley, Belfast City Hospital; David Honeybourne, Birmingham Heartlands Hospital; Anthony Choules, Burton Hospital NHS Foundation Trust; Alison Betteridge, Louise Brown, Vicky Kelly, Derriford Hospital, Plymouth; Julie Mould, Mary Raeburn-Binns, Hull Royal Infirmary; Fiona Lindsay, James Cook University Hospital; Nicola Culley, Rebecca Heise, Caroline Elson, Hilary Wyatt, King's College Hospital NHS Trust; Karolina Oracz, Leeds Teaching Hospitals NHS Trust; Julie Ellison, Leighton Hospital NHS Trust; Lance Dennard, Peggy Burr, Lewisham Healthcare NHS Trust; Irene Moon, Medway NHS Foundation Trust; Karen Heslop, Newcastle upon Tyne Hospital NHS Foundation Trust; Jonathan McCormack, Ninewells Hospital and Medical School; Chris Upton, Norfolk & Norwich University Hospital; Janet Collinson, Northampton General Hospital; Charles Haworth, Papworth Hospital NHS Foundation Trust; Judith Young, Queen Elizabeth Hospital, King's Lynn; Irene Pucci, Royal Aberdeen Children's Hospital; Susan Madge, Royal Brompton Hospital; Caroline Somerville, Royal Cornhill Hospital; Alexander J Moorcroft, Martyn Rees, Royal Shrewsbury Hospital; Mary Carroll, Alison Pearce, Southampton General Hospital; Sandra Hall, The Noah's Ark Children's Hospital for Wales; Rosemary Raynor, Kathleen Thicket, Vicky Williams, The Royal Wolverhampton Hospitals NHS Trust; Cara Davies, University Hospitals Bristol NHS Foundation Trust; Ian Ketchell, University Hospital Llandough; Siobhan Davies, Warren Lenney, Justin Lim, Sarah Whewall, University Hospital of North Stafford; Helen Oxley, University Hospital of South Manchester; Kevin Southern, University of Liverpool).