Original ArticleProtease–antiprotease imbalances differ between Cystic Fibrosis patients' upper and lower airway secretions
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Graphical abstract
Abbreviations
BAL
bronchoalveolar lavage
BALF
bronchoalveolar lavage fluid
BOS
bronchiolitis obliterans syndrome
CF
Cystic Fibrosis
CRS
chronic rhinosinusitis
CTSS
cathepsin S
ECM
extracellular matrix
IFN
interferon
IL
interleukin
LAW
lower airways
LTx
lung transplantation
MHC
major histocompatibility complex
MMP
matrix metalloproteinase
MN
mononuclear
NE
neutrophil elastase
NLF
nasal lavage fluid
NL
nasal lavage
PMN
polymorphonuclear
SLPI
secretory leukocyte protease inhibitor
TCC
total cell count
TIMP
tissue inhibitors of metalloproteinase
TNF
tumor necrosis factor
UAW
upper airways
DTT
Dithiothreitol
PA−SA−
not colonized with P. aeruginosa or S. aureus
PA−SA+
not colonized with P. aeruginosa but with S. aureus
PA+SA−
colonized with P. aeruginosa but not with S. aureus
PA+SA+
colonized with P. aeruginosa and S. aureus
Keywords
Protease
Neutrophil elastase
SLPI
Cathepsin
Nasal lavage
Sinonasal
Lung
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