Mini-Focus Issue: Mechanical Circulatory Support: Opportunities and ChallengesInhibition of ADAMTS-13 by Doxycycline Reduces von Willebrand Factor Degradation During Supraphysiological Shear Stress: Therapeutic Implications for Left Ventricular Assist Device-Associated Bleeding
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Key Words
ADAMTS-13
bleeding
doxycycline
heart failure
left ventricular assist device (LVAD)
mechanical circulatory support
shear stress
von Willebrand factor
Abbreviations and Acronyms
ADAMTS-13
a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13
ELISA
enzyme-linked immunosorbent assay
FRET
Förster resonance energy transfer
GST
glutathione-S-transferase
HRP
horseradish peroxidase
LVAD
left ventricular assist device
SDS
sodium dodecyl sulfate
TBS
Tris-buffered saline
TTP
thrombotic thrombocytopenia purpura
vWF
von Willebrand factor
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Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.