Clinical ResearchCoronaryRepeatability of Fractional Flow Reserve Despite Variations in Systemic and Coronary Hemodynamics
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Dr. Nils P. Johnson received internal funding from the Weatherhead PET Center for Preventing and Reversing Atherosclerosis; and has received significant institutional research support from St. Jude Medical (for NCT02184117) and Volcano Corporation (for NCT02328820), makers of intracoronary pressure and flow sensors. Dr. Kirkeeide has received internal funding from the Weatherhead PET Center for Preventing and Reversing Atherosclerosis; and has signed nonfinancial, nondisclosure agreements with St. Jude Medical and Volcano Corporation to discuss coronary physiology projects. Dr. Berry has received institutional research grant support and consultancy agreements from St. Jude Medical. Dr. De Bruyne has received institutional consultancy fees and research support from St. Jude Medical. Dr. Fearon has received institutional research support from St. Jude Medical; and has served as an advisor to HeartFlow Inc. Dr. Oldroyd has received speaker fees from St. Jude Medical, AstraZeneca, and Volcano Corporation. Dr. Pijls has received institutional grant support from St. Jude Medical; serves as a consultant for St. Jude Medical, HeartFlow Inc., and Boston Scientific; and possesses equity in Philips, ASML, and Heartflow. Dr. Gould has received internal funding from the Weatherhead PET Center for Preventing and Reversing Atherosclerosis; and he is the 510(k) applicant for cfrQuant, a software package for quantifying absolute flow using cardiac positron emission tomography. All royalties will go to a University of Texas scholarship fund. The University of Texas has a commercial, nonexclusive agreement with Positron Corporation to distribute and market cfrQuant in exchange for royalties. However, Dr. Gould retains the ability to distribute cost-free versions to selected collaborators for research. Dr. Daniel T. Johnson has reported that he has no relationships relevant to the contents of this paper to disclose.