Original ResearchNOD-Like Receptor Protein 3 Inflammasome Priming and Activation in Barrett’s Epithelial Cells
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open access
Keywords
IL1β
Pyroptosis
Esophageal Squamous Cell
GERD
Cytokine
Abbreviations used in this paper
Ac-YVAD-CHO
acetyl-Tyr-Val-Ala-Asp-CHO
AIM
absent in melanoma
ASC
apoptosis-associated speck-like protein containing a caspase recruitment domain
ATP
adenosine triphosphate
DAMP
damage-associated molecular pattern
GAPDH
glyceraldehyde-3-phosphate dehydrogenase
GERD
gastroesophageal reflux disease
IL
interleukin
LPS
lipopolysaccharide
LDH
lactate dehydrogenase
mRNA
messenger RNA
NF-κB
nuclear factor-κB
NLRP3
NOD-like receptor protein 3
NOD
nucleotide-binding domain, leucine-rich repeat containing proteins
PAMP
pathogen-associated molecular pattern
PBS
phosphate-buffered saline
pro
protein
PRRs
pattern-recognition receptors
qPCR
quantitative reverse-transcription polymerase chain reaction
ROS
reactive oxygen species
RT-PCR
reverse-transcription polymerase chain reaction
siRNA
small interfering RNA
TLR
Toll-like receptor
TNF
tumor necrosis factor
Cited by (0)
Conflicts of interest The authors disclose no conflicts.
Funding Supported by Merit Review Award BX002666 from the US Department of Veterans Affairs Biomedical Laboratory Research Program (S.J.S.), the National Institutes of Health (R01-DK63621 to R.F.S. and S.J.S., K12 HD-068369-01 and K08-DK099383 to E.C., and R01-DK097340 to D.H.W.). This material is the result of work supported with resources and the use of facilities at the Dallas VA Medical Center. The contents do not represent the views of the US Department of Veterans Affairs or the United States Government.
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Authors share co-first authorship.
© 2016 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.