Letter to the EditorPositive link between STAT3 activation and Th17 Cell infiltration to the lesional skin in vitiligo vulgaris☆
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Letter to the Editor
The pathogenesis for vitiligo has not been fully clarified. A recent study suggested important interplay between locally infiltrated Th17 cells and the inhibition of melanocyte activity, and destruction through Th17-related cytokines such as IL-1β, IL-6, IL-17A and TNF-α [1]. Th17 cells develop in the presence of IL-6 and TGF-β from naïve T cells and IL-6 can stimulates the phosphorylation of STAT3 (signal transducer and activator of transcription 3) which contributes to keratinocyte
Acknowledgements
We thank Kenju Nishida, Eriko Nobuyoshi for their expert technical assistance.
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Grant support This work was supported in part by a grant from the Ministry of Education, Culture, Sports, Science and Technology of Japan and a grant from the Ministry of Health, Labor and Welfare.