Letter to the Editor
Morphological character of pseudoxanthoma elasticum observed by multiphoton microscopy

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Cited by (12)

  • Imaging of in vivo pseudoxanthoma elasticum via multiphoton microscopy and optical coherence tomography

    2020, JAAD Case Reports
    Citation Excerpt :

    Based on our literature search, no prior reports of in vivo MPM of PXE have been performed. Ex vivo MPM analysis of PXE has demonstrated similar findings showing higher densities and larger amounts of elastin in the dermis with direct comparison to histopathologic images.5,6 OCT imaging of PXE has shown dermal clusters of hyporeflective aggregates with peripheral clefts, which our images do not show.7

  • Intravital imaging of cutaneous immune responses

    2020, Cellular Immunology
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    Using this property, multiphoton microscopy has been employed to detect abnormalities in elastic fiber in ex vivo human specimens. For example, the morphological features of elastic fiber in pseudoxanthoma elasticum patients, the most frequent degenerative disease of elastic fiber, were described by multiphoton imaging analysis [32]. Live imaging techniques have recently been applied to humans.

  • Development of in vivo imaging

    2016, Allergology International
  • Intravital multiphoton imaging of cutaneous immune responses

    2014, Journal of Investigative Dermatology
    Citation Excerpt :

    Therefore, the analysis using human biological samples is getting more important. MP microscopy is now used as a noninvasive diagnostic tool for human skin diseases, including skin tumors, skin aging, and connective tissue diseases (Tsai et al., 2009; Murata et al., 2013). The attempt to visualize the skin immune responses is, however, just getting started.

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