Article Analysis & Evaluation
Psychological Screening Test Results for Stress, Depression, and Anxiety are Variably Associated With Clinical Severity of Recurrent Aphthous Stomatitis and Oral Lichen Planus

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Article Title and Bibliographic Information

The role of anxiety, depression, and psychological stress on the clinical status of recurrent aphthous stomatitis and oral lichen planus.

Gavic L, Cigic L, Lukenda DB, Gruden V, Pokupec JSG.

J Oral Pathol Med 2014;43(6):410-7.

Reviewers

Saad Alshahrani, MD, Lorena Baccaglini, DDS, MS, PhD

Purpose/Question

In patients with recurrent aphthous stomatitis (RAS) or oral lichen planus (OLP), is there a difference in severity of certain signs or symptoms comparing patients with higher vs. lower screening test results for psychological factors (stress, anxiety, and depression)?

Source of Funding

None stated

Type of Study/Design

Cross-sectional

Level of Evidence

Level 3: Other evidence

Strength of Recommendation grade

Not applicable

Section snippets

Subjects

Participants were recruited from the dental clinic of the School of Medicine at the University of Split in Croatia between July 2011 and December 2012. Overall, 222 participants (110 RAS and 112 OLP) were assessed for eligibility after excluding immunological and hematological causes of the oral lesions. Twenty-two (10%) patients were excluded because of a systemic disease linked to RAS or OLP or because of incomplete data collection. The remaining 102 RAS participants (age 43 ± 8 years;

Commentary and Analysis

RAS is a painful ulcerative oral disease of unknown etiology with an estimated lifetime prevalence of 40%.1 The diagnosis is based on specific anamnestic and clinical criteria.2 RAS occurs primarily during puberty without a clear gender predilection. The most frequently reported factors associated with RAS are age, race, smoking, and local trauma. Investigations of other factors have yielded less consistent associations. OLP is less common, usually occurs later in life, has a female

References (3)

  • J.D. Shulman

    An exploration of point, annual, and lifetime prevalence in characterizing recurrent aphthous stomatitis in USA children and youths

    J Oral Pathol Med

    (2004)
There are more references available in the full text version of this article.

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