Clinical Reviews in Emergency Medicine
A New Diagnostic Approach to the Adult Patient with Acute Dizziness

https://doi.org/10.1016/j.jemermed.2017.12.024Get rights and content

Abstract

Background

Dizziness, a common chief complaint, has an extensive differential diagnosis that includes both benign and serious conditions. Emergency physicians must distinguish the majority of patients with self-limiting conditions from those with serious illnesses that require acute treatment.

Objective of the Review

This article presents a new approach to diagnosis of the acutely dizzy patient that emphasizes different aspects of the history to guide a focused physical examination with the goal of differentiating benign peripheral vestibular conditions from dangerous posterior circulation strokes in the emergency department.

Discussion

Currently, misdiagnoses are frequent and diagnostic testing costs are high. This relates in part to use of an outdated, prevalent, diagnostic paradigm. The traditional approach, which relies on dizziness symptom quality or type (i.e., vertigo, presyncope, or disequilibrium) to guide inquiry, does not distinguish benign from dangerous causes, and is inconsistent with current best evidence. A new approach divides patients into three key categories using timing and triggers, guiding a differential diagnosis and targeted bedside examination protocol: 1) acute vestibular syndrome, where bedside physical examination differentiates vestibular neuritis from stroke; 2) spontaneous episodic vestibular syndrome, where associated symptoms help differentiate vestibular migraine from transient ischemic attack; and 3) triggered episodic vestibular syndrome, where the Dix-Hallpike and supine roll test help differentiate benign paroxysmal positional vertigo from posterior fossa structural lesions.

Conclusions

The timing and triggers diagnostic approach for the acutely dizzy patient derives from current best evidence and offers the potential to reduce misdiagnosis while simultaneously decreases diagnostic test overuse, unnecessary hospitalization, and incorrect treatments.

Introduction

Approximately 3.5% of emergency department (ED) visits are for dizziness 1, 2. Using the fewest possible resources, physicians must distinguish between the large majority of dizzy patients with self-limiting or easily treatable conditions and the minority with life- or brain-threatening conditions. Compared to those without dizziness, dizzy patients undergo more testing, more imaging, have longer ED lengths of stay, and are more likely to be admitted (1). In 2013, total health care–related costs for patients with dizziness in the United States was estimated to exceed $10 billion 3, 4. Additional “costs” included adverse events, such as patient anxiety, injuries from falls, and preventable major strokes following misdiagnosed minor cerebrovascular events (5).

The existing diagnostic paradigm for dizziness, based on symptom quality or type of dizziness (i.e., asking the question “what do you mean ‘dizzy’?”), is taught across specialties; however, newer research has questioned its scientific basis (6). Taking a history from a dizzy patient should be no different than taking a history in other patients. The timing, triggers, and evolution over time; associated symptoms; and context (and not the descriptor used) best inform the differential diagnosis (7). Bedside examination can frequently establish a specific diagnosis (8). A confident diagnosis of a peripheral vestibular problem obviates the need for specialty consultation, expensive imaging, and hospitalization. When the evaluation suggests a central problem, especially stroke, steps can be taken to prevent harm by early initiation of secondary stroke prevention for milder presentations or thrombolysis or surgical interventions for more malignant presentations (9). We propose a new diagnostic algorithm to guide one's approach to the acutely dizzy patient (see Figure 1). In this article, we use the general term dizziness to encompass various words patients use to describe disturbed balance or spatial orientation, such as lightheaded, spinning, rocking, vertigo, off balance, and others.

Section snippets

Differential Diagnosis

Numerous conditions cause acute dizziness. A study from a national database (National Hospital Ambulatory Medical Care Survey), over a 13-year period, of 9472 patients with dizziness reported general medical (including non-stroke cardiovascular) diagnoses (∼50%), otovestibular diagnoses (∼33%), and neurologic (including stroke) diagnoses (∼11%) (1). In this study, 22% of patients received a symptom-only dizziness (not otherwise specified) diagnosis. Although assigning a symptom-only diagnosis

Diagnostic Pitfalls

In a retrospective German study of 475 consecutive ED dizzy patients seen by neurologists (who routinely performed a detailed ocular motor examination using Frenzel lenses), the neurologists diagnosed benign conditions in 73% of cases and serious conditions (mostly cerebrovascular and inflammatory CNS disease) in 27% of cases (24). A neurologist masked to the initial ED visit changed the diagnosis at follow-up in 44% of those revisiting within 30 days. Benign vestibular diagnoses were deemed

Goals of Care

Primary goals of care in ED patients with dizziness not due to medical causes are to differentiate benign peripheral vestibular conditions from posterior circulation strokes or other dangerous causes (rather than to make a definitive diagnosis) and to manage symptoms appropriately before discharge in those who do not have serious diseases. It is usually the case that a definitive, final diagnosis is not the goal of ED care. However, with dizziness, the most certain way to “rule out” dangerous

A New Diagnostic Paradigm

A new diagnostic paradigm is based on the timing, triggers, associated symptoms, and context of the dizzy symptoms. Although the use of this new paradigm has not yet been proven to reduce misdiagnosis in prospective clinical trials, it is supported by a very strong evidence base in the specialty literature; it is also noteworthy that the traditional paradigm is not evidence-based and likely predisposes to misdiagnosis 16, 44. We believe that this new method allows one to confidently make an

Conclusions

Dizziness, vertigo, and unsteadiness are common complaints caused by numerous diseases that span organ systems. Diagnosis can be difficult. Misconceptions, resource overutilization, and misdiagnosis are common. The current “symptom quality” paradigm was created 45 years ago and is not evidence-based; a newer paradigm, based on timing and triggers, is more consistent with best evidence. History and physical examination are more accurate than imaging, and more likely to result in a specific

Acknowledgments

Dr. Newman-Toker's effort was supported by a grant from the National Institutes of Health (NIDCD U01 DC013778). The funding agency was not involved in design of the study, the collection, analysis, and interpretation of the data, or the decision to approve publication of the finished manuscript.

Both Dr. Edlow and Dr. Newman-Toker review medical-legal cases for both plaintiff and defense firms in cases involving neurologic conditions, including dizziness and stroke. Dr. Newman-Toker has

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