Letter to the EditorPositron emission tomography is not a reliable method for the early diagnosis of cholangiocarcinoma in patients with primary sclerosing cholangitis
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Cited by (42)
EASL Clinical Practice Guidelines on sclerosing cholangitis
2022, Journal of HepatologyCitation Excerpt :Imaging positron emission tomography (PET) has been suggested as a diagnostic tool to complement cross-sectional imaging.296 This technique lacks specificity and sensitivity for detection of CCA, especially in PSC.297–299 False-positive results are seen in cases with active inflammation and bacterial cholangitis.
Intrahepatic cholangiocarcinoma
2014, Surgical Oncology Clinics of North AmericaCitation Excerpt :The utility of PET-CT in the initial diagnosis and staging of suspected ICC is unclear. Studies have been mixed, with some finding a sensitivity and specificity greater than 85%,35,36 whereas others observed limited specificity in the presence of infectious or inflammatory processes.37,38 Patients who present with a hepatic lesion, biopsy-proven to be adenocarcinoma with an unknown primary lesion, represent special diagnostic cases.
Positron Emission Tomography/Computed Tomography of the Solid Parenchymal Organs
2014, Textbook of Gastrointestinal Radiology: Volumes 1-2, Fourth EditionThe role of <sup>18</sup>F-fluorodeoxyglucose positron emission tomography in the diagnosis, staging, and follow-up of cholangiocarcinoma
2011, Surgical OncologyCitation Excerpt :Other investigators reported that no false positive results were observed in patients that had only primary sclerosing cholangitis [37]. However, Fevery et al. [46] reported that 18FDG-PET is not reliable for the diagnosis of cholangiocarcinoma in patients with primary sclerosing cholangitis because they noted 2 false-positive and 1 false-negative results out of 10 patients. Whether 18FDG-PET can replace conventional CT in the discrimination of malignant-vs.-benign diseases in the bile duct is still controversial.
Update on primary sclerosing cholangitis
2010, Digestive and Liver DiseaseCitation Excerpt :In case of pathological findings, CT typically supplements with information on lymph node enlargement and the liver parenchyma [152,154] and has been reported superior to MR imaging in terms of defining extra-hepatic growth and vascular encasement [155,156]. Positron emission tomography (PET) scanning is useful for detecting solid metastases [157], but has in recent studies proven unreliable for detecting peritoneal carcinomatosis or biliary lesions not visible on MRI/CT [158–160]. By cholangioscopy, a sensitivity of 92% and specificity of 93% in the diagnosis of malignant strictures in PSC were recently reported [161], as compared with 66% and 51%, respectively, for ERC alone.