Elsevier

Journal of Hepatology

Volume 59, Issue 5, November 2013, Pages 1094-1106
Journal of Hepatology

Review
Hepatic ischemia and reperfusion injury: Effects on the liver sinusoidal milieu

https://doi.org/10.1016/j.jhep.2013.06.017Get rights and content
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Summary

Ischemia-reperfusion injury is an important cause of liver damage occurring during surgical procedures including hepatic resection and liver transplantation, and represents the main underlying cause of graft dysfunction post-transplantation. Cellular and biochemical processes occurring during hepatic ischemia-reperfusion are diverse and complex, and include the deregulation of the healthy phenotype of all liver cellular components. Nevertheless, a significant part of these processes are still unknown or unclear. The present review aims at summarizing the current knowledge in liver ischemia-reperfusion, but specifically focusing on liver cell phenotype and paracrine interaction deregulations. Moreover, the most updated therapeutic strategies including pharmacological, genetic and surgical interventions, as well as some of the scientific controversies in the field will be described. Finally, the importance of considering the subclinical situation of liver grafts when translating basic knowledge to the bedside is discussed.

Abbreviations

I/R
ischemia-reperfusion
LSEC
liver sinusoidal endothelial cells
KC
Kupffer cells
HSC
hepatic stellate cells
NAD
nicotinamide adenine dinucleotide
ROS
reactive oxygen species
NO
nitric oxide
ET
endothelin
TXA2
thromboxane A2
KLF2
Kruppel-like factor 2
eNOS
endothelial nitric oxide synthase
TNF
tumour necrosis factor
IL
interleukin
INF-γ
interferon-gamma
ICAM-1
intracellular adhesion molecule-1
MIP-2
macrophage inflammatory protein-2
ENA-78
epithelial neutrophil activating protein-78
CINC
cytokine-induced neutrophil chemoattractant-1
GM-CSF
granulocyte-macrophage colony-stimulating factor
GdCl3
gadolinium chloride
NFκB
nuclear factor kappa B
HO-1
heme oxygenase-1
PPAR
peroxisome proliferator-activated receptor

Keywords

Transplantation
KLF2
Endothelium
Hepatocyte
LSEC

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